Cognitive impairment in patients with Parkinson's disease

Authors

Keywords:

Parkinsons disease, cognitive dysfunction, mini mental test, clock drawing test

Abstract

Introduction: Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder. The presence of cognitive impairment is one of the non-motor symptoms that a patient with Parkinson's disease may present; it is very important because it affects, in particular, executive, attentional, visuospatial and memory domains.
Objective: to determine the relationship between the presence of cognitive impairment and the clinical characteristics of patients with Parkinson's disease belonging to the Municipality of Cifuentes.
Methods: a descriptive, cross-sectional, observational study was carried out in the health areas of Cifuentes from October 2013 to October 2019. The study population consisted of 34 patients, the population coincides with the study sample.
Results: 76.47% of the study patients presented cognitive impairment compared to 64.70% of the patients who were found to be cognitively impaired (according to the clock drawing test). A trend is observed, both with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale and with the Hoehn and Yarh scale, that the greater the degree of severity, the greater the prevalence of cognitive impairment.
Conclusions: patients between 61 and 70 years of age and male sex have a higher risk of developing Parkinson's disease. According to the clock drawing test and the mini-mental state examination, patients with Parkinson's disease with cognitive impairment predominated. There was a tendency that the higher the degree of severity, the higher the prevalence of cognitive impairment.

Downloads

Download data is not yet available.

Author Biography

Lázaro Aurelio Vázquez Gómez, Hospital Provincial Clínico Quirúrgico Universitario "Arnaldo Milián Castro"

Especialista en I Grado en Neurología. Profesor Asistente en la Universidad de Ciencias Médicas de Villa Clara.

References

1. Simón Pérez E, Aguilera Pacheco OR, Núñez Lahera I, Colina Avila E. Síntomas no motores en pacientes con enfermedad de Parkinson. MEDISAN [Internet]. 2017 Jun [citado 15/03/2019];21(6):681-687. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192017000600006&lng=es

2. Bocanegra Y, Trujillo-Orrego N, Pineda D. Dementia and mild cognitive impairment in Parkinson’s disease: a review. Rev Neurol [Internet]. 2014 Dec [citado 15/03/2019];59(12):555-69.Disponible en: https://pubmed.ncbi.nlm.nih.gov/25501454/

3. Aarsland D, Creese B, Politis M, Chaudhuri KR, Fytche DH, Weintraub D, et al. Cognitive decline in Parkinson disease. Nat Rev Neurol [Internet]. 2017 Apr [citado 15/03/2019];13(4):217-31. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643027/. https://dx.doi.org/10.1038/nrneurol.2017.27

4. Aarsland D, Zaccai J, Brayne C. A systematic review of prevalence studies of dementia in Parkinson’s disease. Mov Disord [Internet]. 2005 Oct [citado 15/03/2019];20(10):1255-63. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16041803/. https://doi.org/10.1002/mds.20527

5. Galtier I, Nieto A, Lorenzo JN, Barroso J. Mild cognitive impairment in Parkinson’s disease: Diagnosis and progression to dementia. J Clin Exp Neuropsychol [Internet]. 2016 Nov [citado 15/03/2019];38(1):40-50. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26602176/. https://doi.org/10.1080/13803395.2015.1087465

6. GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol [Internet]. 2019 May [citado 15/03/2019];18(5):459-480. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459001/. https://dx.doi.org/10.1016/S1474-4422(18)30499-X

7. Winter Y, von Campenhausen S, Arend M, Longo K, Boetzel K, Eggert K, et al. Health-Related Quality of Life and Its Determinants in Parkinson’s Disease: Results of an Italian Cohort study. Parkinsonism & Related Disorders [Internet]. 2011 May [citado 15/03/2019];17(4):265–9. Disponible en: https://www.scirp.org/(S(351jmbntvnsjt1aadkposzje))/reference/ReferencesPapers.aspx?ReferenceID=1211288. http://dx.doi.org/10.1016/j.parkreldis.2011.01.003

8. Erro R, Stamelou M. Chapter Two - The Motor Syndrome of Parkinson’s Disease. En: Bhatia KP, Chaudhuri KR, Stamelou M, editores. Int Rev Neurobiol [Internet]. 2017 [citado 27/06/2018];132:25-32. Disponible en: http://www.sciencedirect.com/science/article/pii/S0074774217300041. https://doi.org/10.1016/bs.irn.2017.01.004

9. Guevara Silva E, Flores Mendoza M, Torres Ramírez L. Evaluación del deterioro cognitivo en pacientes con enfermedad de Parkinson mediante el test del dibujo del reloj. Diagnóstico. 2010;49(1):11-16.

10. Cuba. Ministerio de Salud Pública. Dirección Nacional de Registros Médicos y Estadística de Salud. Anuario Estadístico de Salud 2018 [Internet]. La Habana: MINSAP; 2019 [citado 22/05/2019]. Disponible en: http://files.sld.cu/bvscuba/files/2019/04/Anuario-Electr%C3%B3nico-Espa%C3%B1ol-2018-ed-2019.pdf

11. Teodoro T, Edwards MJ, Isaacs JD. A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review. J Neurol Neurosurg Psychiatry [Internet]. 2018 Dic [citado 13/05/2019];89(12):1308-19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288708/. https://dx.doi.org/10.1136/jnnp-2017-317823

12. Simón Pérez E, Aguilera Pacheco OR, Núñez Lahera I, Colina Avila E. Síntomas no motores en pacientes con enfermedad de Parkinson. MEDISAN [Internet]. 2017 Jun [citado 13/05/2019];21(6):681-687. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192017000600006

13. Rodríguez Violante M, Villar Velarde A, Valencia Ramos C, Cervantes Arriaga A. Características epidemiológicas de pacientes con enfermedad de Parkinson de un hospital de referencia en México. Arch Neurocien (Mex) [Internet]. 2011 [citado 15/05/2019];16(2):64-68. Disponible en: https://www.medigraphic.com/pdfs/arcneu/ane-2011/ane112d.pdf

14. Diazgranados Sánchez JA, Chan Guevara L, Gómez Betancourt LF, Lozano Arango AF,Ramirez M. Descripción de la población de pacientes con enfermedad de Parkinson en un centro médico neurológico en la ciudad de Cali, Colombia. Acta Neurol Colomb [Internet]. 2011 [citado 15/05/2019];27(4):205-210. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-87482011000400003

15. Cereda E, Cilia R, Klersy C, Siri C, Pozzi B, Reali E, et al. Dementia in Parkinson’s disease: Is male gender a risk factor? Parkinsonism Relat Disord [Internet]. 2016 May [citado 15/05/2019];26:67-72. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26952697/. https://doi.org/10.1016/j.parkreldis.2016.02.024

16. Isais Millán S, Piña Fuentes D, Guzmán Astorga C, Cervantes Arriaga A, Rodríguez Violante M. Prevalencia de trastornos neuropsiquiátricos en pacientes con enfermedad de Parkinson (EP) no tratados. Gac Med Mex [Internet]. 2016 [citado 15/05/2019];152(3):357-63. Disponible en: https://www.medigraphic.com/pdfs/gaceta/gm-2016/gm163l.pdf

17. Pfeiffer HCV, Lokkegaard A, Zoetmulder M, Friberg L, Werdelin L. Cognitive impairment in early-stage non-demented Parkinson’s disease patients. Acta Neurol Scand [Internet]. 2014 May [citado 15/05/2019];129(5):307-18. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24117192/. https://doi.org/10.1111/ane.12189

Downloads

Published

2021-02-17

How to Cite

1.
Vázquez Gómez LA. Cognitive impairment in patients with Parkinson’s disease. Acta Méd Centro [Internet]. 2021 Feb. 17 [cited 2025 Jul. 1];15(2):280-7. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/1338

Issue

Vol. 15 No. 2 (2021): April-June

Section

Original Articles

License

Authors who have publications with this journal agree to the following terms:

  1. Authors will retain their copyright and assign to the journal the right of first publication of their work, which will simultaneously be subject to a Creative Commons License / Attribution-Noncommercial 4.0 International (CC BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
  2. Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g., depositing it in an institutional repository or publishing it in a monographic volume) as long as the initial publication in this journal is indicated.
  3. Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).