The exfoliative cytology in the early diagnosis of the oral cancer
Keywords:
oral cancer, diagnosis method, biopsy, exfoliative cytologyAbstract
Introduction: the early diagnosis is a key factor in the management of an oral cancer, so, it is very important the implementation of simple, not harmful and liable diagnosis method. In this sense, the interest in oral cytology has increased for diagnosing and monitoring.Objetive: to determine the usefulness of exfoliative cytology in the brushiness as a method for the early diagnosis in oral cancer.
Methos: a descriptive, cross-sectional, quanti-qualitative and double blind study was made in the Maxillofacial Surgery service from Arnaldo Milián Castro Hospital, between March 2016 and October 2017. The sample was set by 33 patients who had oral lesions with suspicion of malignancy or premalignancy.
Results: there was a predomination in the masculine sex (63,6%) and those whose ages were between 60 and 69 years (33,3%). The sample with dental brush was painless for the 45,5% of patients; while 54,5% of them referred slight discomfort. There was a concordance of 0,89 according to Kappa index between the presence of neoplastic cells that were detected trough cytology and biopsy with a high diagnostic value of test, with positive predictive value (0,95) and negative predictive value (0,93). According to the grade of differentiation of the malignant tumor, the concordance between both methods was slight (0,094).
Conclusions: the cytology was a useful method for the diagnosis of oral cancer, that showed a coincidence with the histopathological diagnosis in predomination way.
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1. Escalona Veloz R. Diagnóstico histopatológico de cáncer bucal en el Hospital General Docente “Dr. Juan Bruno Zayas Alfonso”. MEDISAN [Internet]. 2015 Feb [citado 20/10/2018];19(2):223-228. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192015000200011
2. Acha A, Ruesga MT, Rodríguez MJ, Martínez de Pancorbo MA, Aguirre JM. Aplicaciones de la citologia oral por raspado (exfoliativa) en el cáncer y precáncer oral. Med Oral Patol Oral Cir Bucal [Internet]. 2005 Mar-Apr [citado 20/10/2018];10(2):95-102. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-44472005000200001
3. Herrera YA, Piña Sánchez P. Historia de la evolución de las pruebas de tamizaje en el cáncer cervicouterino. Rev Med Inst Mex Seguro Soc [Internet]. 2015 [citado 20/10/2018];53(6):670-7. Disponible en: http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/rt/printerFriendly/96/233
4. Diniz Freitas M, García García A, Crespo Abelleira A, Martins Carneiro JL, Gándara Rey JM. Aplicaciones de la citología exfoliativa en el diagnóstico del cáncer oral. Med Oral Patol Oral Cir Bucal (Ed.impr.) [Internet]. 2004 Oct [citado 20/10/2018];9(4):355-361. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-44472004000400014
5. Ceccotti EL, Sforza RR, Carzoglio JC, Luberti R, Flichman JC. El Diagnóstico en Clínica Estomatológica. 1ra ed. Buenos Aires: Editorial Médica Panamericana; 2007.
6. García-Roco Pérez O, Arredondo López M, Álvarez Navarro MC. Citología exfoliativa en el diagnóstico precoz de lesiones oncológicas bucales. Rev Cubana Estomatol [Internet]. 2002 May-Ago [citado 20/10/2018];39(2):89-100. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072002000200002
7. Estrada Pereira GA, Márquez Filiu M, González Heredia E, Nápoles Pruna MM, Ramón Jiménez R. Infección por virus del papiloma humano en la cavidad bucal. MEDISAN [Internet]. 2015 Mar [citado 20/10/2018];19(3):300-306. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192015000300002
8. Rodríguez Guerrero K, Clavería Clark RA, Peña Sisto M. Consideraciones actuales sobre envejecimiento y cáncer bucal. MEDISAN [Internet]. 2016 Dic [citado 20/10/2018];20(12):25-6. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192016001200
9. Diéguez Pérez AR, Correa Rodríguez R, Fonseca del Rey S, Diéguez Pérez LB, Sardiña Hernández Y, Cedeño Gomez Y. Caracterización del cáncer bucal en la Isla de Juventud. 2007 - 2018. Rev Med Isla Juventud [Internet]. 2019 [citado 03/03/2021];20(1):[aprox. 15 p.]. Disponible en: http://www.remij.sld.cu/index.php/remij/article/view/216/420
10. Elzaurdín Mora RA, Lara Fernández N. Tratamiento combinado en cáncer de lengua. Rev Cubana Otorrinolaringol Cirug Cabeza Cuello [Internet]. 2021 [citado 03/03/2021];5(1):e181. Disponible en: http://www.revotorrino.sld.cu/index.php/otl/article/view/181/350
11. Rodríguez Martín O, Betancourt Valladares M, García Ranero AB, Giance Paz L. Pronóstico de incidencia y mortalidad del cáncer bucal en la provincia Ciego de Ávila. Rev Cubana Estomatol [Internet]. 2017 Jul-Sep [citado 20/10/2018];54(3):[aprox. 11 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072017000300005
12. González Y, Nieves Y, Quintero A. La Citología como un método preventivo de infecciones precursoras de lesiones de la cavidad oral [tesis]. Bárbula: Universidad de Carabobo; 2016 [citado 20/10/2018]. Disponible en: http://mriuc.bc.uc.edu.ve/bitstream/handle/123456789/5849/yugonzalez.pdf
13. Santana Garay JC. Atlas de patología del complejo bucal. 2da ed. La Habana: Editorial Ciencias Médicas; 2010.
14. Fuentes Y, Guzmán A, Monsalve L, Palencia D. Utilidad de la citología oral como método diagnóstico del virus del papiloma humano [tesis]. Valencia: Universidad de Carabobo; 2016 [citado 20/10/2018]. Disponible en: http://mriuc.bc.uc.edu.ve/bitstream/handle/123456789/6260/yufuentes.pdf
15. Pereda Rojas ME, González Cardona Y, Torres Herrera LW. Actualización sobre liquen plano bucal. CCM [Internet]. 2016 Jul-Sep [citado 20/10/2018];20(3):539-51.Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1560-43812016000300009
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15 junio 2025
