Predictive index for risk stratification of venous thromboembolic disease in patients with hematologic malignancies

Authors

Keywords:

venous thromboembolic disease, hematological malignancies, prediction index, efficacy

Abstract

Introduction: venous thromboembolic disease is a frequent complication in hematologic malignancies and has a significant impact on morbidity and mortality. Despite the existence of multiple well-validated scores to stratify the risk of this disease in solid tumors, hematological malignancies are underrepresented in these models.
Objective: to design a predictive index for the stratification of the thrombotic risk in patients with hematologic malignancies.
Methods: an analytical observational study of cases and controls was carried out in the “Arnaldo Milián Castro” Hospital from Villa Clara Province, during the period from October 2016 to January 2019, in 285 hospitalized patients with hematological malignancies (94 with thromboembolic disease and 191 without). For univariate analysis, Chi-square test, Odds Ratio for risk estimation and Cramer's V for strength of association were applied. Logistic regression and ROC curve were applied in the multivariate analysis.
Results: the predictive index of thromboembolic disease was composed of five predictors: hypercholesterolemia, tumor activity, immobility, use of thrombogenic drugs and diabetes mellitus. High risk of thrombosis was defined as a patient who scored four points or more and low risk as a patient who scored less than four points. The index correctly classified 81.10% of the patients, for a sensitivity of 59.57% and a specificity of 92.15%. The positive and negative predictive values were 78.87% and 82.24%, respectively.
Conclusions: the developed index represented a specific and effective tool for the prediction of thromboembolic disease in hospitalized patients with hematologic malignancy.

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Author Biographies

Agnerys López Sacerio, Hospital Provincial Clínico Quirúrgico Unversitario "Arnaldo Milián Castro"

Especialista en I Grado en Medicina General Integral. Especialista en I Grado en Hematología. Profesora Auxiliar en la Universidad de Ciencias Médicas de Villa Clara.

Sadys Rendón Peralta, Hospital Provincial Pediátrico Universitario "José Luis Miranda"

Especialista en I Grado en Medicina General Integral. Especialista en I Grado en Hematología.

Eduardo Eligio Barreto Fiu, Universidad de Ciencias Médicas de Villa Clara

Licenciado en Cibernética Matemática. Máster en Computación Aplicada. Profesor Auxiliar en la Universidad de Ciencias Médicas de Villa Clara.

Norisbel Alvarez Basulto, Hospital Universitario "Amalia Simone"

Especialista en I Grado en Hematología

Mailyn Acosta Alvarez, Hospital Provincial Clínico Quirúrgico Unversitario "Arnaldo Milián Castro"

Especialista en I Grado en Medicina General Integral. Especialista en I Grado en Hematología.

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Published

2021-10-14

How to Cite

1.
López Sacerio A, Rendón Peralta S, Barreto Fiu EE, Alvarez Basulto N, Acosta Alvarez M. Predictive index for risk stratification of venous thromboembolic disease in patients with hematologic malignancies. Acta Méd Centro [Internet]. 2021 Oct. 14 [cited 2025 Jul. 14];15(4):511-20. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/1391

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Original Articles