Determinants in overall survival in invasive breast carcinomas clinical and morphological prognostic factors. Assessment of tumor volume

Abstract

The clinical and morphological prognostic factors were evaluated regarding their predictive capacity on the evolutionary appearance of death in patients with invasive breast carcinoma. Material and method: a nonrandom sample of 373: it was defined a women with invasive breast carcinomas by a period of 15 years (1992-2007). Results: the death event occurred more frequently before the first five years of evolution. 87 patients died with an overall survival of 76.7% and an average of 13.53 years. From the evaluated factors the most contributed to overall survival were: tumor position in the lower inner quadrant, with 21patients -10 of them died, 52.4% overall survival and an average of 4.35 years; bilateralism, with 12 patients –seven of them died, 41.7% overall survival and an average of 7.27 years; tumor volume of more than 125cm3, with six patients – three died, 50.0% survival and an average of 8.87 years; nodal status with more than three metastatic nodes, with 77 patients -33 died, 57.1% overall survival and an average of 8.54 years; the presence of periganglionar infiltration tumor, with 72 patients -31 dead, 56.9% of overall survival and an average of 8.63 years; involvement of level III, with 53 patients died -20 died, 62.3% survival and an average of 9.47 years; the modified histological grade poorly differentiated, with 116 patients -41 died, 64.7% overall survival and an average of 11.84 years and the mitotic count with more than 22 mitoses per field further increase with 65 cases -26 dead, 60.0% overall survival and an average of 11.24 years. Conclusion: tumor volume can be considered a morphological prognosis factor determinant in overall survival in infiltrating breast cancer.