Pure neural leprosy. Case report
Keywords:
pure neural leprosy, biopsy, hypoesthesiaAbstract
Introduction: Hansen's disease or leprosy is an infectious and contagious disease of chronic evolution caused by a bacillus, Mycobacterium leprae. Pure, or primary, neural leprosy presents as peripheral neuropathy without the presence of skin lesions.Patient information: a young man, 19 years old, was presented with a history of sensory alterations in both legs of approximately two months of evolution. Physical examination revealed hypoesthesia in patches in both lower limbs. Diagnostic confirmation was established by biopsy of the sural nerve. Antileprosy treatment was started and clinical improvement was achieved with few weeks of evolution.
Conclusions: clinical diagnosis is difficult and the disease may go unnoticed for years, with neural damage with increasing disability, so an exhaustive clinical approach is required to achieve accurate diagnoses. Multidisciplinary management improves the prognosis and quality of life of patients with this disease.
Downloads
References
1.Blanco Córdova CA, Claxton Louit M. Lepra lepromatosa. Presentación de un caso. Medisur [Internet]. 2018 Ago [citado 19/09/2020];16(4):593-598. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2018000400015
2.Inzunza-Cervantes G, García-Tinoco RM, Ahumada-Félix SR, Valenzuela-Delgado SY, Peña-Valenzuela AN. Lepra lepromatosa con reacción tipo II, panorama de una enfermedad milenaria en el siglo XXI: Presentación de caso. Rev Med UAS [Internet]. 2021 Jun [citado 12/08/2021];11(2):136-147. Disponible en: http://hospital.uas.edu.mx/revmeduas/articulos/v11/n2/lepra.html. http://dx.doi.org/10.28960/revmeduas.2007-8013.v11.n2.007
3.Martínez Collado N, Valle Sánchez C, Sánchez Hernández K. Lepra lepromatosa. Presentación de caso. Rev Méd Electrón [Internet]. 2012 Ago [citado 19/09/2020];34(4):496-502. Disponible en: http://scielo.sld.cu/pdf/rme/v34n4/tema11.pdf
4.Job CK, Jayakumar J, Kearney M, Gillis TP. Transmission of leprosy: a study of skin and nasal secretions of household contacts of leprosy patients using PCR. Am J Trop Med Hyg [Internet]. 2008 [citado 19/09/2020];78(3):518-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18337353/
5.Kotteeswaran G, Chacko CJ, Job CK. Skin adnexa in leprosy and their role in the dissemination of M. leprae. Lepr India [Internet]. 1980 [citado 19/09/2020];52(4):475-481. Disponible en: https://pubmed.ncbi.nlm.nih.gov/7007723/
6.Rodríguez G, Pinto R. Lepra neural primaria: definición y criterios de manejo. Rev Asoc Colomb Dermatol [Internet]. 2010 [citado 19/09/2020];18(2):91-5.Disponible en: https://revistasocolderma.org/articulo-revista/lepra-neural-primaria-definicion-y-criterios-de-manejo
7.Lee D, Modlin R. Leprosy. En: Fitzpatrick TB, Goldsmith LA, editores. Fitzpatrick's dermatology in general medicine. 8va ed. New York: Mcgraw-Hill Medical; 2012.
8.Aridon P, Ragonese P, Mazzola MA, Terruso V, Palermo A, D'Amelio M, et al. Leprosy: report of case with severe peripheral neuropathy. Neurol Sci [Internet]. 2010 [citado 19/09/2020];31(1):75-77. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19812892/. https://doi.org/10.1007/s10072-009-0152-5
9.González RR. La lepra no constituye un problema de salud en Cuba [Internet]. Santa Clara: Vanguardia; 2019 [citado 19/09/2020]. Disponible en: http://www.vanguardia.cu/villa-clara/13197-lepra-no-constituye-un-problema-de-salud-en-cuba
10.Aparecida Silva E, Sammarco Rosa P, Fernandes Belone AF, Broch Coelho NM, Ura S, Tomimori J. Serodiagnosis of leprosy and follow-up of household contacts using a commercial rapid test containing ND-O/LID-1 antigens. Lepr Rev [Internet]. 2017 [citado 19/09/2020];88:174-183. Disponible en: https://leprosyreview.org/admin/public/api/lepra/website/getDownload/5f5129662bea3019726d5b7f
11.Zúñiga M, Bertoló MS, Arias F, Torres Z, Poulain C, Avendaño M, et al. Manual de organización y procedimientos para la lepra (Enfermedad de Hansen) [Internet]. Santiago de Chile: Ministerio de Salud; 2017 [citado 19/09/2020]. Disponible en: https://diprece.minsal.cl/wrdprss_minsal/wp-content/uploads/2017/12/2017.12.21_MANUAL-DE-LEPRA.pdf
12.Organización Mundial de la Salud. Global Leprosy Strategy 2016 – 2020. Accelerating towards a leprosy-free world. Monitoring and Evaluation Guide [Internet]. Ginebra: OMS; 2017 [citado 19/09/2020]. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/254907/9789290225492-eng.pdf
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms:
- Authors will retain their copyright and assign to the journal the right of first publication of their work, which will simultaneously be subject to a Creative Commons License / Attribution-Noncommercial 4.0 International (CC BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
- Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g., depositing it in an institutional repository or publishing it in a monographic volume) as long as the initial publication in this journal is indicated.
- Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).
15 junio 2025
