Clinical and epidemilogical characterization of patients with Rheumatoid Arthritis and cardiorespiratory manifestations
Keywords:
arthritis rheumatoid, extra-articular, cardiorespiratory manifestationsAbstract
Introduction: rheumatoid arthritis is a systemic, inflammatory and autoimmune disease that can affect, in addition to the joints, other organs such as the heart and lungs.Objective: clinical and epidemiological characterization of patients with rheumatoid arthritis who presented cardiorespiratory manifestations.
Methods: a cross-sectional descriptive study was carried out in 62 patients with cardiorespiratory manifestations treated in Arnaldo Milián Castro Hospital`s Rheumatology Service from January 2017 to December 2018.
Results: the average age was 52,9 years old and female (6:1), white skin color, rural origin and occupation worker or retired predominated. Hypertension was the most frequent pathological antecedent found. Valvular insufficiency occurred in 35,5% and pericarditis in 32,3% of the patients studied. Cardiac conduction disorders and ventricular hypertrophy were evidenced in 12,9% of cases. Moderate restrictive pattern was the most frequent in respiratory function tests. 41.9% of patients were treated with steroids and disease-modifying antirheumatic drugs.
Conclusions: the high frequency of cardiorespiratory manifestations related to the evolution of rheumatoid arthritis was confirmed.
Downloads
References
1.Mercado U, Barbosa B. Manifestaciones extraarticulares de artritis reumatoide. Med Int Méx [Internet]. 2016 [citado 21/08/2021];32(6):607-611. Disponible en: https://www.medigraphic.com/pdfs/medintmex/mim-2016/mim166b.pdf
2.Grupo de trabajo de la GUIPCAR. Guía de Práctica Clínica para el Manejo de Pacientes con Artritis Reumatoide [Internet]. Madrid: Sociedad Española de Reumatología; 2018 [citado 21/08/2021]. Disponible en: https://www.ser.es/wp-content/uploads/2018/09/Gu%C3%ADa-de-Pr%C3%A1ctica-Cl%C3%ADnica-para-el-Manejo-de-Pacientes-con-Artritis-Reumatoide.pdf
3.Camargo JF, Tobón GJ, Anaya JM. Resorción ósea en artritis reumatoidea: aspectos moleculares y correlación radiológica. Medunab [Internet]. 2003 [citado 21/08/2021];6(18):148-154. Disponible en: https://revistas.unab.edu.co/index.php/medunab/article/view/246/229
4.Cardiel MH, Latin American Rheumatology Associations of the Pan-American League of Associations for Rheumatology (PANLAR), Grupo Latinoamericano de Estudio de Artritis Reumatoide (GLADAR). First Latin American Position Paper on the Pharmacological Treatment of Rheumatoid Arthritis. Rheumatology Oxford [Internet]. 2006 [citado 21/08/2021];45(Suppl 2):ii7-ii22. Disponible en: https://pubmed.ncbi.nlm.nih.gov/16709584/. https://doi.org/10.1093/rheumatology/kei500
5.Armas Rodríguez WE, Alarcón Medina GA, Ocampo Dávila FD, Arteaga CM, Arteaga Paredes PA. Artritis reumatoide, diagnóstico, evolución y tratamiento. Rev Cuba Reumatol [Internet]. 2019 [citado 21/08/2021];21(3):e114. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-59962019000300013&lng=es
6.Alunno A, Gerli R, Giacomelli R, Carubbi F. Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis. Biomed Res Int [Internet]. 2017 [citado 21/08/2021]; 2017:7915340. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697381/. https://doi.org/10.1155/2017/7915340
7.Pérez-Dórame R, Mejía M, Mateos-Toledo H, Rojas-Serrano J. Rheumatoid arthritis-associated interstitial lung disease: lung inflammation evaluated with high resolution computed tomography scan is correlated to rheumatoid arthritis disease activity. Reumatol Clin [Internet]. 2015 [citado 21/08/2021];11(1):12-16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24913966/. https://doi.org/10.1016/j.reuma.2014.02.007
8.Nurmohamed MT. Cardiovascular risk in rheumatoid arthritis. Autoimmun Rev [Internet]. 2009 [citado 21/08/2021];8(8):663-667. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19393192/. https://doi.org/10.1016/j.autrev.2009.02.015
9.Amital A, Shitrit D, Adir Y. The lung in rheumatoid arthritis. Presse Med [Internet]. 2011 [citado 21/08/2021];40(1 Pt 2):e31-48. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21196098/. https://doi.org/10.1016/j.lpm.2010.11.003
10.Erickson A, Cannella A, Mikuls T. Características clínicas de la artritis reumatoide. En: Kelley y Firestein. Tratado de Reumatología. 10ma ed. Amsterdan: Elsevier; 2018.
11.Chico Capote A, Uguña San F, Estévez del Toro M, Rodríguez López M, Hidalgo Costa T. Riesgo cardiovascular en pacientes con artritis reumatoide. Acta Méd [Internet]. 2019[citado 21/08/2021];20(2):e03. Disponible en: http://www.revactamedica.sld.cu/index.php/act/article/view/24/14
12.National Institutes of Health [Internet]. Bethesda: NIH; 2021 [actualizado 01/05/2017; citado 21/08/2021]. ¿Tiene dolor en las articulaciones?; [aprox. 4 pantallas]. Disponible en: https://salud.nih.gov/articulo/tiene-dolor-en-las-articulaciones/
13.Mora C, González A, Quintana G. Guía de tratamiento de la artritis reumatoide temprana en un Hospital Universitario de Colombia. Rev Colomb Reumatol [Internet]. 2008 [citado 21/08/2021];15(2):79-91. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232008000200003
14.Carmona Ferrer B, Almanza Díaz Y, Arbelo Figueredo M, Herrera Gato R, Vázquez González T. Osteoartritis en adultos mayores atendidos en el Hospital de Rehabilitación “Julio Díaz”. Rev Cubana Med Fís Rehabilit [Internet]. 2021 [citado 13/12/2021];13(3):e594. Disponible en: http://revrehabilitacion.sld.cu/index.php/reh/article/view/594
15.de Armas Hernández A, Solís Cartas U, Prada Hernández DM, Benítez Falero Y, Vázquez Abreu RL. Factores de riesgo ateroscleróticos en pacientes con artritis reumatoide. Rev Cub Med Mil [Internet]. 2017 [citado 21/08/2021];46(1):51-63. Disponible en: http://www.revmedmilitar.sld.cu/index.php/mil/article/view/5/40
16.Vasquez Castillo MA. Comorbilidades de pacientes con artritis reumatoide, Lima - Perú [tesis]. Lima: Universidad Peruana Cayetano Heredia; 2020 [citado 21/08/2021]. Disponible en: https://repositorio.upch.edu.pe/bitstream/handle/20.500.12866/7833/Comorbilidades_VasquezCastillo_Manuel.pdf
17.Díaz Cuña C, Consani S, Torres V, Alonso F, Berez A. Estudio multicéntrico descriptivo de enfermedades pulmonares intersticiales asociadas a enfermedades autoinmunes en centros de salud en Montevideo, Uruguay. Rev Urug Med Int [Internet]. 2018 [citado 21/08/2021];3(3):12–19. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S2393-67972018000300012. https://doi.org/10.26445/03.01.1
18.Ahern M, Lever JV, Cosh J. Complete heart block in rheumatoid arthritis. Ann Rheum Dis [Internet]. 1983 [citado 21/08/2021];42(4):389-397. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001249/. https://doi.org/10.1136/ard.42.4.389
19.Apolo-Izquierdo YL, Vaca-Pino XK, Santos-Meza JJ, Bravo-Amores AC. Lesiones cardiacas asociadas a enfermedades Reumatológicas. Polo Conoc [Internet]. 2020 [citado 21/08/2021];5(11):717-732. Disponible en: https://polodelconocimiento.com/ojs/index.php/es/article/view/2085/4162. https://doi.org/10.23857/pc.v5i11.2085
20.Almodóvar R, Joven BE, Serrano MP, Galindo M, Carreira PE, Mateo I. Pericarditis exudativoconstrictiva en paciente con artritis reumatoide. Rev Esp Reumatol [Internet]. 2003 [citado 21/08/2021];30(3):139-141. Disponible en: https://www.elsevier.es/es-revista-revista-espanola-reumatologia-29-articulo-pericarditis-exudativoconstrictiva-paciente-con-artritis-13045267
21.Esposito AJ, Chu SG, Madan R, Doyle TJ, Dellaripa PF. Thoracic manifestations of rheumatoid arthritis. Clin Chest Med [Internet]. 2019 [citado 21/08/2021];40(3):545-560. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994971/. https://doi.org/10.1016/j.ccm.2019.05.003
22.Bonilla Hernán MG, Gómez-Carrera L, Fernández-Velilla Peña M, Álvarez-Sala Walther R, Balsa A. Prevalencia y características clínicas de la enfermedad pulmonar intersticial difusa sintomática en la artritis reumatoide en una población española. Rev Clín Esp [Internet]. 2022 [citado 29/05/2022];222(5):281-287. Disponible en: https://www.sciencedirect.com/science/article/pii/S0014256521000783. https://doi.org/10.1016/j.rce.2021.01.010
23.Toledo-Pereda MV, Noel Rivero M, Díaz C, Consani S. Manifestaciones pulmonares de la artritis reumatoide. A propósito de un caso clínico. Rev Esp Casos Clin Med Intern [Internet]. 2019 [citado 21/08/2021];4(2):54-56. Disponible en: https://www.reccmi.com/RECCMI/article/view/371. https://doi.org/10.32818/reccmi.a4n2a5
24.O’Dell R. Tratamiento de la artritis reumatoide. En: Kelley y Firestein. Tratado de Reumatología. 10ma ed. Amsterdan: Elsevier; 2018.
Downloads
Published
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms:
- Authors will retain their copyright and assign to the journal the right of first publication of their work, which will simultaneously be subject to a Creative Commons License / Attribution-Noncommercial 4.0 International (CC BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
- Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g., depositing it in an institutional repository or publishing it in a monographic volume) as long as the initial publication in this journal is indicated.
- Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).
15 junio 2025
