Malignant transformation of a Giant Cell Tumor: a case report

Authors

Keywords:

giant cell tumor, malignant transformation, amputation

Abstract

Introduction: the knee is the anatomical region where most benign and malignant tumors affecting the human skeleton are found, including giant cell tumor.
Patient information: male, 28 years old, white, with no morbid health history, who came to the Orthopedics and Traumatology outpatient clinic for presenting a tumor at the level of the right knee accompanied by pain that appeared two years ago, but has increased in size rapidly in the last two months. Imaging tests and incisional biopsy were performed to confirm the diagnosis. The multidisciplinary team decided to amputate the limb.
Conclusions: giant cell tumor is a disease that occurs more frequently from the third to the fifth decade of life; its main complications are recurrence, pulmonary metastasis and malignant transformation. Patients with the latter complication require procedures such as limb amputation.

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Author Biographies

Alejandro Álvarez López, Hospital Provincial Pediátrico Universitario "Dr. Eduardo Agramonte Piña"

Especialista de I y II Grado en Ortopedia y Traumatología. Máster en Urgencias Médicas. Doctor en Ciencias Médicas. Profesor e Investigador Titular, Universidad de Ciencias Médicas de Camagüey.

Maikel Fernández Delgado, Hospital Provincial Clínico Quirúrgico Universitario "Manuel Ascunce Domenech"

Especialista de I Grado en Ortopedia y Traumatología

Yenima de la Caridad García Lorenzo, Policlínico Universitario "Tula Aguilera"

Especialista de I Grado en Medicina General Integral. Profesora Asistente en la Universidad de Ciencias Médicas de Camagüey.

Johenis Creagh García, Hospital Provincial Clínico Quirúrgico Universitario "Manuel Ascunce Domenech"

Especialista de I Grado en Anatomía Patológica. Profesora Asistente en la Universidad de Ciencias Médicas de Camagüey.

References

1. Kalil RK, Amary F. Giant Cell Tumor of Bone. En: Santini Araujo E, Kalil RK, Bertoni F, Park YK. Tumors and Tumors-Like Lesions of Bone. 2nd ed. Berlín: Springer; 2020. p. 381-397.

2. Cheng X, Su Y, Huang M. Bone Tumor Imaging. Singapore: Springer Singapore; 2020. p. 53-58.

3. Basu Mallick A, Chawla SP. Giant cell tumor of bone: an update. Curr Oncol Rep [Internet]. 2021 [citado 12/08/2021];23(5):51. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33754215/. https://doi.org/10.1007/s11912-021-01047-5

4. Jamshidi K, Karimi A, Mirzaei A. Epidemiologic characteristics, clinical behavior, and outcome of the giant cell tumor of the bone: a retrospective single-center study. Arch Bone Jt Surg [Internet]. 2019 [citado 12/08/2021];7(6):538-544. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935520/

5. Ariga A, Kanda H, Ando Y, Gokita T. Giant cell tumor with atypical imaging implying osteosarcoma. Clin Nucl Med [Internet]. 2020 [citado 12/08/2021];45(11):892-893. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32796245/. https://doi.org/10.1097/rlu.0000000000003226

6. Montgomery C, Couch C, Emory CL, Nicholas R. Giant cell tumor of bone: review of current literature, evaluation, and treatment options. J Knee Surg [Internet]. 2019 [citado 12/08/2021];32(4):331-336. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30449024/. https://doi.org/10.1055/s-0038-1675815

7. Alaqaili SI, Abduljabbar AM, Altaho AJ, Khan AA, Alherabi JA. Malignant sarcomatous transformation of benign giant cell tumor of bone after treatment with Denosumab therapy: a literature review of reported cases. Cureus [Internet]. 2018 [citado 12/08/2021];10(12):e3792. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402735/. https://doi.org/10.7759/cureus.3792

8. van der Heijden L, Dijkstra S, van de Sande M, Gelderblom H. Current concepts in the treatment of giant cell tumour of bone. Curr Opin Oncol [Internet]. 2020 [citado 12/08/2021];32(4):332-338. Disponible en: https://journals.lww.com/co-oncology/Fulltext/2020/07000/Current_concepts_in_the_treatment_of_giant_cell.14.aspx. https://doi.org/10.1097/cco.0000000000000645

9. Roessner A, Smolle M, Haybäck J. Giant cell tumor of bone: morphology, molecular pathogenesis, and differential diagnosis. Pathologe [Internet]. 2020 [citado 12/08/2021];41(2):134-142. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32086536/. https://doi.org/10.1007/s00292-020-00760-5

10. Chen W, Yan Z, Tirumala V. Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy. J Orthop Res [Internet]. 2020 [citado 12/08/2021];38(10):2139-2148. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32293747/. https://doi.org/10.1002/jor.24698

11. Lin JL, Wu YH, Shi YF, Lin H, Nisar M, Meftah Z, et al. Survival and prognosis in malignant giant cell tumor of bone: a population-based analysis from 1984 to 2013. J Bone Oncol [Internet]. 2019 [citado 12/08/2021];19:100260. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812025/. https://doi.org/10.1016/j.jbo.2019.100260

12. Palmerini E, Picci P, Reichardt P, Downey G. Malignancy in giant cell tumor of bone: a review of the literature. Technol Cancer Res Treat [Internet]. 2019 [citado 12/08/2021];18:1533033819840000. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446439/. https://doi.org/10.1177/1533033819840000

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Published

2023-03-29

How to Cite

1.
Álvarez López A, Fernández Delgado M, García Lorenzo Y de la C, Creagh García J. Malignant transformation of a Giant Cell Tumor: a case report. Acta Méd Centro [Internet]. 2023 Mar. 29 [cited 2025 Jun. 27];17(2):332-9. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/1775

Issue

Vol. 17 No. 2 (2023): Abril-Junio

Section

Case Reports

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