Depression in Idiopathic Parkinson’s Disease Patients

Authors

Keywords:

Parkinson´s disease, motor signs, depression

Abstract

Introduction: depression is the most common neuropsychiatric disorder among people with Parkinson's disease and its prevalence ranges from 2.7% to 90%.
Objective: to establish the relationship between the intensity of depressive symptoms, severity of motor signs and decreased ability to perform activities of daily living.
Methods: a cross-sectional descriptive study was conducted in the Neurology Consultation in patients with idiopathic Parkinson's disease residing in the Municipalities of Santo Domingo and Santa Clara, Villa Clara Province, from January 2017 to January 2019; the sample consisted of 35 patients. The program Statistical Package for the Social Sciences version 21.0 was used in the data analysis. Descriptive statistical methods were used.
Results: there was a significant relationship between the duration of the disease and the intensity of depression. It was determined that the greater the intensity of depression, the worse the motor and functional performance, which coincides with stage III of the Hoehn and Yahr scale.
Conclusions: the greater intensity of depressive symptoms contributed to worse motor and functional performance in these patients.

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Author Biographies

Humberto Raúl Alvarez Luna, Hospital Provincial Pediátrico Universitario "José Luis Miranda"

Especialista de I Grado en Medicina General Integral. Especialista de I Grado en Neurología. Máster en Psicología Médica. Profesor Asistente en la Universidad de Ciencias Médicas de Villa Clara.

Leonardo Rodríguez Méndez, Universidad Central Marta Abreu de Las Villas

Licenciado en Psicología. Doctor en Ciencias Psicológicas. Profesor Titular en la Universidad Central Marta Abreu de Las Villas.

References

1.Alvarez Sintes R. Atención al adulto mayor. En: Alvarez Sintes R, Hernández Cabrera GV, García Núñez RD, Barcos Pina I, Báster Moro JC. Medicina General Integral. 4ta ed. Tomo I. Vol. 2. La Habana: Editorial Ciencias Médicas, 2014 [citado 08/04/2023]. p. 154-182. Disponible en: http://www.bvscuba.sld.cu/libro/medicina-general-integral-tomo-i-salud-y-medicina-vol-2-4ta-ed

2.Montoya Zamora PC, Rodríguez Castañeda F. Enfermedades neurodegenerativas en adultos mayores: retos en el diagnóstico y tratamiento. Ibn Sina [Internet]. 2022 [citado 08/04/2023];13(2):1-9. Disponible en: https://revistas.uaz.edu.mx/index.php/ibnsina/ article/view/1311/1280

3.Alemán Pullas SL, Montero Balarezo CX, Díaz Recalde EX, Jarro Sanchez CM. Enfermedad de Parkinson. Diagnóstico y tratamiento. Recimundo [Internet]. 2022 [citado 08/04/2023];6(2):250-266. Disponible en: https://recimundo.com/index.php/es/article/view/1566. https://doi.org/10.26820/recimundo/6.(2).abr.2022.250-266

4.Chaves Morales K, Padilla Elizondo DS, Vargas Fernández R. Enfermedad de Parkinson. Rev Méd Sinerg [Internet]. 2022 [citado 08/04/2023];7(2):e758. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/758. https://doi.org/10.31434/rms.v7i2.758

5.Verdecia Aguilar M, Jacas Cabrera A, Milanés Domínguez J, Frias Viltres D, Odoardo Aguilar M. Caracterización de los síntomas no motores en pacientes con enfermedad de Parkinson. Multimed [Internet]. 2022 [citado 08/04/2023];26(5):e2471. Disponible en: http://scielo.sld.cu/pdf/mmed/v26n5/1028-4818-mmed-26-05-e2471.pdf

6.Dahbour SS, Al Murr MJ, Oweis LH, Al Antary NT, Mohsen M, Al Fegi S. Non-motor manifestations of Parkinson´s disease: a cross-sectional study in a teaching hospital in Jordan. Egypt J Neurol Psychiatry Neurosurg [Internet]. 2022 [citado 08/04/2023];58:148. Disponible en: https://ejnpn.springeropen.com/articles/10.1186/s41983-022-00559-6. https://doi.org/10.1186/s41983-022-00559-6

7.Rai AK, Ranjan A, Mudassir S, Kumar A. Patter of non motor symptoms in Parkinson´s disease: a prospective observational study from a tertiary care centre, Bihar, India. J Clin Diagn Res [Internet]. 2022 [citado 08/04/2023];16(9):1-4. Disponible en: https://www.jcdr.net/articles/PDF/16845/56861_CE(OM)_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdf. https://doi.org/10.7860/JCDR/2022/56861.16845

8.Samushiya MA, Ragimova AA, Smolentseva IG, Maksimenko MY, Ivannikova EI. Affective and personality disorders in Parkinson´s disease premotor phase. Pilot study. Cogn Remediat J [Internet]. 2020 [citado 08/04/2023];9(1):1-8. Disponible en: https://cognitive-remediation-journal.com/artkey/crj-202001-0001_affective-and-personality-disorders-in-parkinson-s-disease-premotor-phase-pilot-study.php. https://doi.org/10.5507/crj.2020.001

9.Lin W, Wang D, Yang L, Zhu J, Ge J, Zuo C, et al. Does the personality of patients with Parkinson´s disease affect the decision to perform deep brain stimulation surgery? A cross-sectional study in a Chinese cohort. Behav Neurol [Internet]. 2021 [citado 08/04/2023];2021:6639255. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857895/. https://doi.org/10.1155/2021/6639255

10.De Lucia N, De Rosa A, Perillo S, Sperandeo R, De Michele G, Maldonato NM. Introversion and neuroticism in akinetic-rigid Parkinson´s disease: association with frontal-executive-dysfunction. J Neuropsychiatry Clin Neurosci [Internet]. 2023 [citado 08/04/2023];35(3):228-235. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36999250/. https://doi.org/10.1176/appi.neuropsych.20220115

11.Henderson E, Torsney KM, Scourfield L, Jones S, Berryman K. Neuropsychiatric symptoms in Parkinson´s disease: aetiology, diagnosis and treatment. BJ Psych Advances [Internet]. 2020 [citado 08/04/2023];(6):333-342. Disponible en: https://www.cambridge.org/core/product/identifier/S2056467819000793/type/journal_article. https://doi.org/10.1192/bja.2019.79

12.Weintraub D, Aarsland D, Chaudhuri KR, Dobkin RD, Leentjens AF, Rodriguez-Violante M, et al. The neuropsychiatry of Parkinson´s disease: advances and challenges. Lancet Neurol [Internet]. 2022 [citado 08/04/2023];21(1):89-102. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800169/. https://doi.org/10.1016/S1474-4422(21)00330-6

13.Tripathi A, Gupta PK, Bansal T. Management of psychiatric disorders in patients with Parkinson´s diseases. Indian J Psychiatry [Internet]. 2022 [citado 08/04/2023];64(Suppl 2):S330-S343. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122177/. https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_29_22

14.Chikatimalla R, Dasaradhan T, Koneti J, Cherukuri SP, Kalluru R, Gadde S. Depression in Parkinson´s disease: a narrative review. Cureus [Internet]. 2022 [citado 08/04/2023];14(8):e27750. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447473/. https://doi.org/10.7759/cureus.27750

15.Prange S, Klinger H, Laurencin C, Danaila T, Thobois S. Depression in patients with Parkinson´s disease: current understanding of its neurobiology and implications for treatment. Dugs Aging [Internet]. 2022 [citado 08/04/2023];39(6):417-439. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200562/. https://doi.org/10.1007/s40266-022-00942-1

16.Olivares Romero J. Criterios diagnósticos. En: Escamilla Sevilla F, González Torres V, Moya Molina MA, editores. Recomendaciones de práctica clínica en la enfermedad de Parkinson. Barcelona: Editorial Glosa, S.L.; 2022 [citado 08/04/2023]. p. 37-48. Disponible en: https://www.saneurologia.org/wp-content/uploads/2022/11/recomendaciones-practica-clinica-enfermedad-parkinson-2022-1.pdf

17.Jesús Maestre S, Mir Rivera P. Escalas de evaluación recomendadas en el diagnóstico y seguimiento. En: Escamilla Sevilla F, González Torres V, Moya Molina MA. Recomendaciones de práctica clínica en la enfermedad de Parkinson. Barcelona: Editorial Glosa, S.L.; 2022 [citado 08/04/2023]. p. 87-99. Disponible en: https://www.saneurologia.org/wp-content/uploads/2022/11/recomendaciones-practica-clinica-enfermedad-parkinson-2022-1.pdf

18.Martín-Carbonell M, Riquelme-Marín A, Ortigosa-Quiles JM, Meda RM, Cerquera-Córdoba AM, Enríquez-Santos JA, et al. Utilidad del Inventario de Depresión Rasgo-Estado (IDERE) para el diagnóstico clínico. Un estudio con muestras de cuatro países iberoamericanos. An Psicol [Internet]. 2012 [citado 08/04/2023];28(3):763-771. Disponible en: https://www.redalyc.org/articulo.oa?id=16723774014. http://dx.doi.org/10.6018/analesps.28.3.133701

19.Organización Panamericana de la Salud. Temas de salud. Depresión [Internet]. Washington DC: OPS; 2023 [citado 08/04/2023]. Disponible en: https://www.paho.org/es/temas/depresion

20.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Washington DC: APA; 2022 [citado 08/04/2023]. Disponible en: https://dsm.psychiatryonline.org/doi/book/10.1176/appi.books.9780890425787

21.Stella F, Bucken-Gobbi LT, Gobbi S. Síntomas depresivos y trastorno motor en pacientes con enfermedad de Parkinson. Rev Neurol [Internet]. 2007 [citado 08/04/2023];45(10):594-598. Disponible en: https://neurologia.com/articulo/2007235. https://doi.org/10.33588/rn.4510.2007235

22.Rojo A, Aguilar M, Garolera MT, Cubo E, Navas I, Quintana S. Depression in Parkinson’s disease: clinical correlates and outcome. Parkinsonism Relat Disord [Internet]. 2003 [citado 08/04/2023];10(1):23-28. Disponible en: https://pubmed.ncbi.nlm.nih.gov/14499203/. https://doi.org/10.1016/s1353-8020(03)00067-1

23.Gupta A, Bhatia S. Psychological functioning in patients with Parkinson’s disease. Parkinsonism Relat Disord [Internet]. 2000 [citado 08/04/2023];6(3):185-190. Disponible: https://pubmed.ncbi.nlm.nih.gov/10817960/. https://doi.org/10.1016/s1353-8020(00)00010-9

24.Holroyd S, Currie LJ, Wooten GF. Depression is associated with impairment of ADL, not motor function in Parkinson disease. Neurology [Internet]. 2005 [citado 08/04/2023];64(12):2134-2135. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15985588/. https://doi.org/10.1212/01.wnl.0000165958.12724.0d

25.Errea Abad JM, Ara JR. Depresión y enfermedad de Parkinson. Rev Neurol [Internet]. 1999 [citado 08/04/2023];28(7):694-698. Disponible en: https://www.neurologia.com/articulo/98173. https://doi.org/10.33588/rn.2807.98173

26.Serrano-Dueñas M. Enfermedad de Parkinson, hemicuerpo afectado y depresión. Rev Neurol [Internet]. 2000 [citado 08/04/2023];31(12):1109-1112. Disponible en: https://neurologia.com/articulo/2000290/esp. https://doi.org/10.33588/rn.3112.2000290

27.Chakraborty A, Diwan A. Depression and Parkinson´s disease: a chicken-egg story. AIMS Neurosci [Internet]. 2022 [citado 08/04/2023];9(4):479-490. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826748/. https://doi.org/ 10.3934/Neuroscience.2022027

28.Song S, Luo Z, Li C, Huang X, Shiroma EJ, Simonsick EM, et al. Depressive symptoms before and after Parkinson´s diagnosis— A longitudinal analysis. PLoS One [Internet]. 2022 [citado 08/04/2023];17(7):e0272315. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337685/. https://doi.org/10.1371/journal. pone.0272315

29.Ribeiro Artigas N, Leonardi Dutra AC, Medeiros Soares N, Magalhães Pereira G, Bielefeldt Leotti V, Schneider Krimberg J, et al. Depressive symptoms and axial motor disorders in individuals with Parkinson´s disease: a cross-sectional study. Arq-Neuropsiquiatr [Internet]. 2022 [citado 08/04/2023];80(11):1126-1133. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797277/. https://doi.org/10.1055/s-0042-1758444

30.Starkstein SE, Petracca G, Chemerinski E, Tesón A, Sabe L, Merello M, et al. Depression in classic versus akinetic-rigid Parkinson’s disease. Mov Disord [Internet]. 1998 [citado 08/04/2023];13(1):29-33. Disponible en: https://pubmed.ncbi.nlm.nih.gov/9452322/. https://doi.org/10.1002/mds.870130109

Published

2023-10-31

How to Cite

1.
Alvarez Luna HR, Rodríguez Méndez L. Depression in Idiopathic Parkinson’s Disease Patients. Acta Méd Centro [Internet]. 2023 Oct. 31 [cited 2025 Jun. 27];17(4):694-706. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/1966

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Original Articles