Aneurysmal bone cyst

Authors

Keywords:

bone cyst; , aneurysmal bone cyst, osteolytic lesion, recurrence, pathologic fracture

Abstract

Introduction: Osteolytic bone lesions have different histological origins; among them the aneurysmal bone cyst is one of the most found in daily medical practice.
Objective: Update knowledge on the most important aspects of aneurysmal bone cyst.
Methods: The search and analysis of the information was carried out over a period of 59 days (January 1, 2025 to February 28, 2025) and the following words were used: aneurysmal bone cyst, bone cyst, osteolitic injury. Based on the information obtained, a bibliographic review of a total of 135 articles published in the databases PubMed, Hinari, SciELO, ResearchGate, Ebsco, Scopus, Medscape and Medline were carried out using the search manager and reference manager EndNote, of which 30 citations were used.
Development: The theories involved in patients suffering from this entity are mentioned, as well as the main clinical manifestations and imaging aspects. Reference is made to the classification described by Capanna and its interpretation. The main differences with the solitary bone cyst, the macro and microscopic characteristics, are described. Reference is made to the treatment modalities and complications related to this bone condition.
Conclusions: The aneurysmal bone cyst is an osteolytic type lesion that is most frequently observed in the first two decades of life. The clinical manifestations of patients with this entity vary from asymptomatic to symptomatic that can even lead to pathological fracture. The treatment is generally surgical where various techniques are applied.

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Author Biographies

Alejandro Álvarez López, "Dr. Eduardo Agramonte Piña", Provincial Pediatric Hospital, Camagüey, Cuba

Doctor of Medical Sciences. Second-Degree Specialist in Orthopedics and Traumatology. Master in Emergency Medicine. Full Professor and Researcher

Eric Urbina Santibañez, School of Kinesiology. Faculty of Health. University of Santo Tomás. Chile

Bachelor of Kinesiology

References

1. Bavan L, Eastley N, Stevenson J, Mifsud M, Bayliss L, Mahmoud S, et al. Aneurysmal bone cysts: a UK wide tumor center experience. J Surg Oncol [Internet]. 2024 [citado 20/02/2025]; 129(3): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37965813/

https://doi.org/10.1002/jso.27499

2. Chaudhary S, Dhawale R, Sawarbandhe S, Agrawal P, Kate A, Sakhare K, et al. Aneurysmal bone cyst of femoral head: a rare case report. J Orthop Case Rep [Internet]. 2025 [citado 20/02/2025];15(1): [aprox. 3p.]. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC11723746/

https://doi.org/10.13107/jocr.2025.v15.i01.5152

3. Jain M, Pradhan SS, Khan S, Tripathy S, Lubaib KP, Raj KS. Aneurysmal bone cyst of the distal ulna in an elderly lady. J Orthop Case Rep [Internet]. 2024 [citado 20/02/2025];14(11): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39524295/

https://doi.org/10.13107/jocr.2024.v14.i11.4922

4. Qadri HM, Khawaja AA, Bashir R, Bashir A. Primary aneurysmal bone cyst of sacrum: a case report of a 12 years old boy from Pakistan. Pak J Med Sci [Internet]. 2024 [citado 20/02/2025];40(12PINS Suppl): S95-S98. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39703962/

https://doi.org/10.12669/pjms.40.12(PINS).10988

5. Erdogan F, Cengiz T, Aydin Simsek S, Say CS, Coskun HS, Dabak N. Infantile aggressive aneurysmal bone cyst of the proximal femur: a rare clinical presentation. Cureus [Internet]. 2024 [citado 20/02/2025];16(12):e75708. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39807466/

https://doi.org/10.7759/cureus.75708

6. Hajialiloo Sami S, Toloue Ghamari B, Kargar Shooroki K, Mohammadi Aniloo F, Ammar W, Rikhtehgar M, et al. Metatarsal aneurysmal bone cysts treated with en bloc resection and reconstruction with fibular allograft. Foot Ankle Int [Internet]. 2025 [citado 20/02/2025]; 46(1):[aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39665486/

https://doi.org/10.1177/10711007241287714

7. Khatib M, Hasani IW. Acetabular aneurysmal bone cyst during the Syrian conflict: a case report of surgical treatment and outcomes. Cureus [Internet]. 2024 [citado 20/02/2025];16(3): e56474. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38638726/

https://doi.org/10.7759/cureus.56474

8. Madani H, El Hassnaoui Y, Ait Benali H, Shimi M. Aneurysmal bone cyst of the calcaneus: A rare case report and review of the literature. Int J Surg Case Rep [Internet]. 2024 [citado 20/02/2025];119: [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38788635/

https://doi.org/10.1016/j.ijscr.2024.109802

9. Price A, Fredricks N, Bartman M, D'Souza P, Hayworth M, Campbell G, et al. Thoracic aneurysmal bone cyst secondary to osteoblastoma: unique surgical management. Illustrative case. J Neurosurg Case Lessons [Internet]. 2024 [citado 20/02/2025];8(21): CASE24471. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39556816/

https://doi.org/10.3171/CASE24471

10. Agarwal D, Sudhakaran D, Mohan A, Das CJ. Preoperative embolisation of aneurysmal bone cyst of sternum. MJ Case Rep [Internet]. 2025 [citado 20/02/2025];18(1): e263875. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39842900/

https://doi.org/10.1136/bcr-2024-263875

11. Gall C, Allison DC. Recurrent aneurysmal bone cyst treated with percutaneous doxycycline sclerotherapy: a case report. JBJS Case Connect [Internet]. 2024 [citado 20/02/2025];14(4): [aprox. 2p.] Disponible en: https://pubmed.ncbi.nlm.nih.gov/39637081/

https://doi.org/10.2106/JBJS.CC.24.00371

12. Cekov A, Tarev I, Kanev A. Spinal aneurysmal bone cysts - case series. Folia Med (Plovdiv) [Internet]. 2024 [citado 20/02/2025]; 66(3): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39365632/

https://doi.org/10.3897/folmed.66.e121395

13. Mejbel HA, Zein-Sabatto B, Wei S, Siegal GP. An aneurysmal bone cyst harboring a novel ACSL4: USP6 fusion gene. J Orthop Sci [Internet]. 2024 [citado 20/02/2025];29(2): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37349178/

https://doi.org/10.1016/j.jos.2023.05.014

14. Shanmuganathan S, Singh SV, Vijayan S, Kulkarni MS. Solid aneurysmal bone cyst of cuboid: rare location and diagnostic conundrum. BMJ Case Rep [Internet]. 2024 [citado 20/02/2025];17(11): e258844. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39532335/

https://doi.org/10.1136/bcr-2023-258844

15. Tiwari V, Sahoo S, Roy M, Dwidmuthe S, Bhavani P, Reddy H. Aneurysmal bone cyst of the third metatarsal treated using free nonvascular fibular strut graft-A rare case report. J Orthop Case Rep [Internet]. 2024 [citado 20/02/2025];14(3): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38560311/

https://doi.org/10.13107/jocr.2024.v14.i03.4318

16. Zellner M, Kellenberger CJ, Pistorius S, Dreher T, Pfammatter T, Knüsel P, et al. Technical feasibility and outcome of cryoablation of aneurysmal bone cysts in pediatric patients. J Vasc Interv Radiol [Internet]. 2024 [citado 20/02/2025];35(11):1655-1661.e2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39111619/

https://doi.org/10.1016/j.jvir.2024.07.027

17. Alhulaimi Y, AlAbbasi KK, AlShaya OS, Alrawaf TN, Aldosari NH, Zogel B. Giant cell tumor with secondary aneurysmal bone cyst in the left distal humerus: a case report. Cureus [Internet]. 2024 [citado 20/02/ 2025];16(7): e65507. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39188432/

https://doi.org/10.7759/cureus.65507

18. Mohapatra S, Pani SK, Khandelwal C, Mishra S, Sharma A. Ipsilateral fibula grafting in a case of aneurysmal bone cyst in tibia diaphysis: a case report. J Orthop Case Rep [Internet]. 2024 [citado 20/02/2025];14(11): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39524269/

https://doi.org/10.13107/jocr.2024.v14.i11.4906

19. Yasin M, Alisi M, Hammad Y, Samarah O, Hassan FA. Treatment of aneurysmal bone cyst by minimally invasive curettage and allogenic bone impaction grafting: mid-to long-term results. Orthop Surg [Internet]. 2022 [citado 20/02/2025];14(12):[aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36250563/

https://doi.org/10.1111/os.13511

20. Ismail A, Ashour A, Alieldin E, Ashour AT, Abouelnaga A, Salama M, et al. Outcomes of non-vascularized fibular grafts in proximal humerus aneurysmal bone cysts. Cureus [Internet]. 2024 [citado 20/02/2025];16(8): e66428. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39246995/

https://doi.org/10.7759/cureus.66428

21. El Khassoui A, Touraif M, Tahiri D, Aghoutane EM, Salama T, El Fezzazi R. Ewing's sarcoma disguised as aneurysmal bone cyst lesion: about a case. Case Rep Oncol Med [Internet]. 2024 [citado 20/02/ 2025]; 2024:3549689. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC11003792/

https://doi.org/10.1155/2024/3549689

22. Gensler R, Roehrkasse A, Dowlati E, Sloan E, McGrail K. Surgical management of a multilevel thoracolumbar aneurysmal bone cyst. BMJ Case Rep [Internet]. 2024 [citado 20/02/2025];17(4): e259708. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38684351/

https://doi.org/10.1136/bcr-2024-259708

23. Galán-Olleros M, Miranda-Gorozarri C, Rey-Cañas R, Alonso-Hernández J, Azorín-Cuadrillero D, Palazón-Quevedo Á. Hexapod frame correction of proximal tibial recurvatum caused indirectly by a femoral aneurysmal bone cyst in an adolescent: a case report and systematic review. JBJS Case Connect [Internet]. 2024 [citado 20/02/2025];14(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/38452160/

https://doi.org/10.2106/JBJS.CC.23.00496

24. Levanon E, Merose O, Segal O, Dadia S, Sternheim A, Levin D, et al. Does cryotherapy decrease the local recurrence rate in the treatment of an aneurysmal bone cyst? A comparative assessment. J Orthop Res [Internet]. 2024 [citado 20/02/2025];42(6): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38146068/

https://doi.org/10.1002/jor.25775

25. Ahmed HA, Almasoudi EA, Nail LL, Samargandi R. Response of recurrent aggressive aneurysmal bone cyst of distal tibia to Denosumab treatment. J Orthop Case Rep [Internet]. 2024 [citado 20/02/2025];14(6): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38910984/

https://doi.org/10.13107/jocr.2024.v14.i06.4538

26. Mahajan NP, Pande KP, Mhatre JA, Chaudhari KM. Management of proximal femur aneurysmal bone cyst with 10-year follow-up - A case report. J Orthop Case Rep [Internet]. 2024 [citado 20/02/ 2025];14(6):[aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38910999/

https://doi.org/10.13107/jocr.2024.v14.i06.4532

27. Long XY, Sun F, Wang T, Li P, Tian Z, Wu XW. Ilizarov technique for treatment of a giant aneurysmal bone cyst at the distal femur: A case report. World J Orthop [Internet]. 2024 [citado 20/02/ 2025];15(11):[aprox. 2p.] Disponible en: https://pubmed.ncbi.nlm.nih.gov/39600861/

https://doi.org/10.5312/wjo.v15.i11.1088

28. Sharma C, Barman S, Bansal S, Panda D, Pranav J, Maheshwari V, et al. Outcomes of a single dose of injection polidocanol application in aneurysmal bone cyst. J Orthop [Internet]. 2023 [citado 20/02/2025];51: [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39600861/

https://doi.org/10.1016/j.jor.2023.11.024

29. Wong MN, Begley KA, Braswell LE, Alexander JH, Lillis AP, Smetzer SM, et al. Doxycycline sclerotherapy of aneurysmal and unicameral bone cysts in the appendicular skeleton and pelvis: single-center 14-year experience. J Vasc Interv Radiol [Internet]. 2024 [citado 20/02/2025];35(12):1785-1792.e5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39265785/

https://doi.org/10.1016/j.jvir.2024.09.001

30. Costa DD, Gabrielli E, Cerrone M, Di Gialleonardo E, Maccauro G, Vitiello R. Pathological fractures in aneurysmal bone cysts: a systematic review. J Clin Med [Internet]. 2024 [citado 20/02/2025];13(9):[aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38731012/

https://doi.org/10.3390/jcm13092485

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Published

2026-02-01

How to Cite

1.
Álvarez López A, Urbina Santibañez E. Aneurysmal bone cyst. Acta Méd Centro [Internet]. 2026 Feb. 1 [cited 2026 Feb. 2];20:e2247. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/2247

Issue

Vol. 20 (2026): PUBLICACIÓN CONTINUA

Section

Review Articles

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Copyright (c) 2026 Alejandro Alvarez López

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