Effectiveness of preventive analgesia with non-steroidal anti-inflammatory drugs in the urgent trauma surgery

Abstract

One hundred and twenty ASA grade I and II patients were prospectively studied. They were randomly assigned in groups of 40: those who received orally, one hour prior to the operation, naproxen (250 mg); those who received ibuprofen (400 mg) and those who received placebo. All of them received general endotracheal anesthesia. The behavior of the respiratory rate, heart rate and systolic and diastolic blood pressures were analyzed at six, 12, 18 and 24 hours after surgery in relation to baseline levels.  The postoperative analgesic quality was assessed according to the visual analogue scale in the aforementioned periods. The incidence of side effects was registered and the analgesia was supplemented with tramadol hydrochloride. Male sex and age group between 36 and 50 years proved to show the highest incidence in the sample. The groups I and II showed better hemodynamic stability with respect to the placebo group. The quality of analgesia was superior in the naproxen group followed by the ibuprofen group. The most frequent side effects were nausea, epigastric pain and headache. It can be said that oral premedication with naproxen and ibuprofen was effective in controlling postoperative pain, with good hemodynamic stability and low incidence of side effects related to their use.