Susceptibility of Mycobacterium tuberculosis strains to antimicobacterial drugs

Authors

Keywords:

Mycobacterium tuberculosis, antimicobacterial drug, susceptibility

Abstract

Introduction: the infections caused by the Mycobacterium tuberculosis complex are the first cause of death by an infectious agent; in recent years there has been the emergence and dissemination of strains resistant to multiple antimicobacterial drugs. Objective: to determine the susceptibility patterns of strains of Mycobacterium tuberculosis isolated in patients of the Villa Clara Province. Methods: a retrospective descriptive study including 116 strains of Mycobacterium tuberculosis isolated in Villa Clara patients from July 2015 to July 2018 was carried out with susceptibility tests performed by the nitrate reductase method, the proportions method and molecular methods. Results: sensitivity to isoniazid and rifampicin was found in 105 strains, four multidrug-resistant strains were found, as well as one extremely resistant strain. Conclusions: Mycobacterium tuberculosis strains in Villa Clara Province mostly show sensitivity patterns, a small number is multidrug-resistant and the number of extremely resistant strains is negligible. The recognition of the low prevalence of these last patterns is a tool for the control of their dissemination in the province.

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Author Biographies

Yoandy Fidel Rivero Pérez, Centro Provincial de Higiene, Epidemiología y Microbiología, Villa Clara

Licenciado en Microbiología

Silvia Mildestein Verdés, Centro Provincial de Higiene, Epidemiología y Microbiología, Villa Clara

Especialista de I Grado en Microbiología Clínica. Máster en Enfermedades Infecciosas. Investigadora Aspirante. Profesora Asistente de la Universidad de Ciencias Médicas de Villa Clara.

Maidelys Mendoza Acosta, Centro Provincial de Higiene, Epidemiología y Microbiología, Villa Clara

Especialista de I y II Grado en Microbiología Clínica. Máster en Enfermedades Infecciosas. Profesora Asistente de la Universidad de Ciencias Médicas de Villa Clara.

Margarita Puerto Díaz, Cardiocentro “Ernesto Guevara”

Especialista de I Grado en Medicina General Integral y en Bioestadística. Máster en Atención Integral a la Mujer.

Dihadenys Lemus Molina, Instituto de Medicina Tropical Pedro Kourí

Licenciada en Microbiología. Máster en Bacteriología y Micología. Doctora en Ciencias de la Salud. Profesora Asistente. Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Micobacterias, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba.

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Published

2019-06-25

How to Cite

1.
Rivero Pérez YF, Mildestein Verdés S, Mendoza Acosta M, Puerto Díaz M, Lemus Molina D. Susceptibility of Mycobacterium tuberculosis strains to antimicobacterial drugs. Acta Méd Centro [Internet]. 2019 Jun. 25 [cited 2025 Jul. 1];13(3):297-303. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/1033

Issue

Vol. 13 No. 3 (2019): July-September

Section

Original Articles

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