Characterization of menopausal women affected by COVID-19

Authors

Keywords:

COVID-19, climacteric stage, intensity of climacteric syndrome, post-COVID endocrinopathies

Abstract

Introduction: coronavirus is a disease caused by the SARS-CoV-2 virus that affected the global population in 2019 (COVID-19 pandemic) and can exhibit unique characteristics in menopausal women.
Objective: to characterize menopausal women affected by COVID-19 at the "Idalberto Revuelta" Polyclinic in Sagua la Grande, Villa Clara.
Methods: a developmental study was conducted, through a descriptive cross-sectional study, in 57 women aged 40 to 59 years affected by COVID-19 from January 2021 to December 2022. Results: Women aged 55 to 59 years (40.35%), postmenopausal women (80.70%), and the subgroup at highest risk for COVID-19 (68.42%) predominated. Complications occurred in 7% of cases, and the most common post-COVID-19 endocrinopathies were subacute thyroiditis (8.77%) and type 2 diabetes mellitus (5.26%).
Conclusions: menopausal women with early postmenopause and a higher risk of COVID-19 complications predominated, which increased as the severity of menopausal syndrome increased. Among the post-COVID-19 endocrinopathies, subacute thyroiditis and type 2 diabetes mellitus were prominent.

Downloads

Download data is not yet available.

Author Biographies

Belkys Consuegra Dreke, “Martyrs of April 9” Hospital, Sagua la Grande, Villa Clara, Cuba.

First-level specialist in MGI and Endocrinology. Instructor professor

Vivian de la Caridad Betancourt Rodríguez, Arnaldo Milián Castro Provincial Clinical and Surgical University Hospital, Santa Clara, Villa Clara, Cuba

Second-level specialist in endocrinology. Assistant professor and consultant.

Noira Durán Morera, Mariana Grajales Coello Maternal Hospital, Santa Clara, Villa Clara, Cuba

First-level specialist in MGI and Biostatistics. Assistant Professor

René Manuel Cruz González, Arnaldo Milián Castro Provincial Clinical and Surgical University Hospital, Santa Clara, Villa Clara, Cuba

1st-level specialist in Endocrinology. Instructor professor

References

1. Okpechi SC, Fong JT, Gill SS, Harman JC, Nguyen TH, Chukwurah QC, et al. Disparidad global por sexo de COVID-19: una revisión descriptiva de las hormonas sexuales y consideración del uso terapéutico potencial de la terapia de reemplazo hormonal en adultos mayores. Aging Dis [Internet]. 2021 [citado 12/11/2024]; 27(1): [aprox. 2p.].Disponible en: https://pmc-ncbi-nlm-nih-gov.translate.goog/articles/PMC7990361/?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

https://doi.org/10.14336/AD.2020.1211

2. Adhikari SP, Meng S, Wu YJ, Mao YP, Ye RX, Wang QZ, et al. Epidemiology,causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty [Internet]. 2020 [citado 12/11/2024]; 9(1): [aprox. 2p.].Disponible en: https://pubmed.ncbi.nlm.nih.gov/32183901/

https://doi.org/10.1186/s40249-020-00646-x

3. Afonso de León JA, Sánchez Barrera O, Rodríguez Curbelo M, García García D, Cañete Villafranca R. Biomodulina T: una nueva opción terapéutica contra la COVID-19. Rev Méd Electrón [Internet]. 2021[citado 12/11/2024]; 43(6): [aprox. 3p.]. Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/42/5322

4. Neyro JL, Cristóbal I. Influencia de la CoVID19 sobre los tratamientos hormonales en Ginecología. Gac Med Bilbao [Internet]. 2020 [citado 12/11/2024]; 117(2): [aprox. 2p.]. Disponible en: https://www.gacetamedicabilbao.eus/index.php/gacetamedicabilbao/article/view/795

5. Rodríguez Cahill C. Cinco retos psicológicos de la crisis del COVID-19. JONNPR [Internet]. 2020 [citado 12/11/2024]; 5(6): [aprox. 2p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2020000600583&lng=es.

https://dx.doi.org/10.19230/jonnpr.3662.

6. García A, Gil JD, Pimiento M, Viveros JA, González AM. El elemento sexo en el COVID-19: mecanismos diferenciales en la susceptibilidad, la severidad y la mortalidad de la enfermedad por SARS-CoV-2. Rev Colomb Endocrinol Diabet Metab [Internet]. 2022 [citado 12/11/2024]; 9(4):e759. Disponible en: https://revistaendocrino.org/index.php/rcedm/article/view/759

https://doi.org/10.53853/encr.9.4.759

7. Wang R, Pan M, Zhang X, Fan X, Han M, Zhao F, et al . Epidemiological and clinical features of 125 Hospitalized Patients withCOVID-19. China International Journal of Infectious Diseases [Internet]. [citado 12/11/2024]; Disponible en: https://pubmed.ncbi.nlm.nih.gov/32289565/

https://doi.org/10.1016/j.ijid.2020.03.070).

8. Tang D, Comish P, Kang R. The hallmarks of COVID-19 disease. PLoS Pathog [Internet]. 2020 [citado 12/11/2024]; 16(5):e1008536.Disponible en: https://pubmed.ncbi.nlm.nih.gov/32442210/

https://doi.org/10.1371/journal.ppat.1008536

9. Navarro Despaine D, Artiles Visbal L. COVID-19: ¿Necesidad de incluir lamenopausia en la evolución de la enfermedad? Anales de la ACC [Internet]. 2021 [citado 12/11/2024]; 11 (1): [aprox. 3p.] Disponible en: https://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2304-01062021000100020&lng=es&nrm=iso>

10. Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL. Considerando cómo el sexo biológicoafecta las respuestas inmunitarias y los resultados de COVID-19. Nat Rev Immunol [Internet]. 2020 [citado 12/11/2024]; 20:[aprox. 3p.].Disponible en: https://www-nature-com.translate.goog/articles/s41577-020-0348-8?error=cookies_not_supported&code=84796b6c-350e-4a1d-aece-d965eceefaf9&_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

https://doi.org/10.1038/s41577-020-0348-8

11. Mishra N, Sharma R, Mishra P, Singh M, Seth S, Deori T, et al. COVID-19 and menstrual status: Is menopause an independent risk factor for SARS Cov-2? J Mid- life Health [Internet]. 2020 [citado 12/11/2024]; 11: [aprox. 3p.].Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7978058/

https://doi.org/10.4103/jmh.JMH_288_20

12. Zhang Y. Vital Surveillances. Características epidemiológicas de un brote de enfermedades causadas por el nuevo coronavirus de 2019 (COVID-19) China, 2020. Epidemiología de la respuesta de emergencia por neumonía por el nuevo coronavirus. China CDC Weekly [Internet]. 2020 [citado 12/11/2024]; 2(8): [aprox. 4p.].Disponible en: https://weekly-chinacdc-cn.translate.goog/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc

https://doi.org/10.46234/ccdcw2020.032

13. Pérez López FR, Tajada M, Savirón Cornudella, R, Sánchez Prieto M, Chedraui P, Terán E. Coronavirus disease 2019 and gender related mortality in European countries: A meta analysis. Maturitas [Internet]. 2020 [citado 12/11/2024]; 141:[aprox. 3p.].Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309755/

https://doi.org/10.1016/j.maturitas.2020.06.017

14. Garg R, Agrawal P, Gautam A, Pursnani N, Agarwal M, Agarwal A, et al. Resultados de COVID‐ 19 en mujeres posmenopáusicas y perimenopáusicas: ¿Se atribuye a los Estrógenos las diferencias? J Midlife Health [Internet]. 2020 [citado 12/11/2024]; 11 (4):[aprox. 3p.].Disponible en: https://pubmed.ncbi.nlm.nih.gov/33767567/

https://doi.org/10.4103/jmh.jmh_287_20

15. Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health [Internet]. 2020 [citado 12/11/2024]; 8: [aprox. 2p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201103/

https://doi.org/10.3389/fpubh.2020.00152

16. Ding T, Zhang J, Wang T, Cui P, Chen Z, Jiang J, et al. A Multi hospital Study in Wuhan, China: Protective Effects of Non menopause and Female Hormones on SARS-CoV-2 infection. Med Rxiv [Internet]. 2020 [citado 12/11/2024]. Disponible en: https://www.medrxiv.org/content/10.1101/2020.03.26.20043943v1

https://doi.org/10.1101/2020.03.26.20043943

17. Trenti A, Tedesco S, Boscaro C, Trevisi L, Bolego C, Cignarella A. Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the Puzzle. Int J Mol Sci [Internet]. 2018 [citado 12/11/2024]; 19(3):[aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29543707/

https://doi.org/10.3390/ijms19030859 PMID:29543707.

18. Liu D, Ding HL, Chen Y, Chen DH, Yang C, Yang LM, et al. Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men. Aging (Albany NY) [Internet]. 2021 [citado 12/11/2024]; 13(18): [aprox. 3p.].Disponible en: https://pubmed.ncbi.nlm.nih.gov/34551393/

https://doi.org/10.18632/aging.203532

19. López M, Vanhauwaert P, Barriga P, Lavin P, Porcila A, Parra M. Manual para Manejo de la Mujer en Edad de Climaterio. 2ed Chile: Sociedad Chilena de Endocrinología Ginecológica [Internet]. Chile: Socheg; 2020 [citado 12/11/2024]. Disponible en: https://www.endogin.org/Manual-Climaterio-SOCHEG-2020.pdf

20. Rivas E, Hernández Gutiérrez C, Zerquera Trujillo G, Vicente Sánchez B, Muñoz Cocina J. Factores biológicos y sociales relacionados con la salud de la mujer durante el climaterio. Medisur [Internet]. 2011 [citado 12/11/2024]; 9(6):[aprox. 4p.]. Disponible en: https://medisur.sld.cu/index.php/medisur/article/view/1212

21. Colectivo de autores. II Consenso Cubano sobre Climaterio y Menopausia. La Habana: Editorial CIMEQ; 2007 [citado 12/11/2024].Disponible en: https://www.sld.cu/galerias/pdf/sitios/ginecobs/consenso2006 seccclimy menop.pdf

22. Wright E, Shaltout O, Zokvic MA, Shirreff L. Delivery of menopause care during a pandemic: an evaluation of patient satisfaction with telephone visits. Menopause [Internet]. 2021 [citado 12/11/2024]; 29(2): [aprox. 4p.].Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785511/

https://doi.org/10.1097/GME.0000000000001906

23. Costeira R, Lee KA, Murray B, Christiansen C, Castillo Fernandez J, Lochlainn MN, et al. Estrogen and COVID‑19 symptoms: associations in women from the COVID Symptom Study. Med Rxiv [Internet]. 2020 [citado 12/11/2024]; 16(9):e0257051. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34506535/

https://doi.org/1 0.1101/2020.07.30.20164921.

24. Navarro Despaigne D, Duany Navarro A, Manzano Ovies B, Sarduy Nápoles M. Una mirada biosocial a las características clínicas de adultos cubanos infectados por el virus SARS CoV2. Revista Cubana de Obstetricia y Ginecología [Internet]. 2020 [citado 12/11/2024]; 46(3):e680. Disponible en: https://revginecobstetricia.sld.cu/index.php/gin/article/view/680/

25. Mangia C, Russo A, Civitelli S, Gianicolo EA. Sex/gender differences in COVID-19 lethality: what the data say, and do not say. Epidemiol Prev [Internet]. 2020 [citado 12/11/2024]; 44(5-6 Suppl 2): [aprox. 3p.].Disponible en: https://pubmed.ncbi.nlm.nih.gov/33412835/

https://doi.org/10.19191/EP20.5-6.S2.145PMID:33412835.

26. Cagnacci A, Xholli A. Change in Covid-19 infection and mortality rates in postmenopausal women. Menopause [Internet]. 2021 [citado 12/11/2024]; 28(5): [aprox. 4p.].Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078005/

https://doi.org/10.1097/GME.0000000000001731

27. Zafari Zangenel F, Sarmast Shoushtari. Estradiol and Covid-19: Doc 17-Estradiol Have an Inmune-Protective Function in women against coronavirus? J Family Reprod Health [Internet]. 2021 [citado 12/11/2024]; 15(3): [aprox. 5p.]. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC8536825/

https://doi.org/10.18502/jfrh.v15i3.7132

28. Correa V, Cabello S, Nilo F, Cerda J. Tiroiditis subaguda asociada a COVID-19: Revisión narrativa. ARS med (Santiago) [Internet]. 2023 [citado 12/11/2024]; 48(2): [aprox. 3p.]. Disponible en: https://www.arsmedica.cl/index.php/MED/article/view/1930

http://dx.doi.org/10.11565/arsmed.v48i2.1930.

29. Ruiz Domínguez R, Patiño Constancio E. Tiroiditis subaguda asociada con covid 19: reporte de tres casos. Rev Méd La Paz [Internet]. 2022 [citado 12/11/2024]; 28(2): [aprox. 4p.]. Disponible en: https://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1726-89582022000200057

30. Lima Martínez MM, Carrera Boada C, Madera Silva MD, Marín W, Contreras M. COVID-19 and diabetes: A bidirectional relationship. Clin Investig Arterioscler [Internet]. 2021 [citado 12/11/2024]; 33(3): [aprox. 2p.].Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598432/

https://doi.org/10.1016/j.arteri.2020.10.001

Published

2025-07-03

How to Cite

1.
Consuegra Dreke B, Betancourt Rodríguez V de la C, Durán Morera N, Cruz González RM. Characterization of menopausal women affected by COVID-19. Acta Méd Centro [Internet]. 2025 Jul. 3 [cited 2025 Jul. 6];19(1):e2279. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/2279

Issue

Section

Original Articles