Small vessel disease in the central nervous system

Authors

  • José Treto Rosal Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba
  • Ana Hortensia Pérez López Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Keywords:

central nervous system, cerebral hemorrhage, cerebral infarction

Abstract

Cerebrovascular disease affects brain arteries by means of occlusion or rupture. Both medium and small sized arteries could be affected. Small vessel occlusion produces lacunar infarcts and small vessel rupture produces intracerebral hemorrhage. Depending on the location and size of the lesion and comorbidity, a wide range of clinical presentation is observed, thus leading to different outcomes. Therapy is mainly aimed at avoiding complications and preventing recurrences.

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Author Biographies

José Treto Rosal, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Neurología

Ana Hortensia Pérez López, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Residente de Neurología

References

1. Adams RD, Victor M, Ropper AH, editores. Principles of Neurology. New York: McGraw-Hill; 1997.

2. Pulsinelli WA. Cerebrovascular diseases. En: Goldman GH, editor. Cecil Textbook of Medicine. 21 ed. Philadelphia: Saunders; 2000. p. 2093-2115.

3. Kulkarni V, Bhagwat N, Hakim A, Kamath S, Soneji SL. Hypertension in the elderly. J Assoc Physicians India. 2001 Sep;49:873-6.

4. De Girolami U, Anthony DC, Frosch MP. The Central Nervous System. En: Cotran TD, editor. Robbins Pathologic Basis of Disease. 6ta. ed. Philadelphia: Saunders; 1999. p. 1293-1314.

5. Cupini LM, Pasqualetti P, Diomedi M, Vernieri F, Silvestrini M, Rizzato B, et al. Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts. Stroke. 2002 Mar;33(3):689-94.

6. Reichart MD, Bogousslavsky J, Janzer RC. Early lacunar strokes complicating polyarteritis nodosa: thrombotic microangiopathy. Neurology. 2000 Feb 22;54(4):883-9.

7. Adams HP Jr, Bendixen BH, Kappelle LJ. Classification of subtypes of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke. 1993;24:35-41.

8. Tsuchiya H. Role of hypertension in stroke in the elderly. Hypertension. 1994 Jan;23(1 Suppl 1):I221-28.

9. Murat Sumer M, Erturk O. Ischemic stroke subtypes: risk factors, functional outcome and recurrence. Neurol Sci. 2002 Mar;22(6):449-54.

10. Nagai Y, Kitagawa K, Sakaguchi M. Significance of earlier carotid atherosclerosis for stroke subtypes. Stroke. 2001 Aug;32(8):1780-5.

11. Wardlaw JM, Dennis MS, Warlow CP, Sandercock PA. Imaging appearance of the symptomatic perforating artery in patients with lacunar infarction: occlusion or other vascular pathology? Ann Neurol. 2001 Aug;50(2):208-15.

12. Arboix A, Garcia-Eroles L, Massons J, Oliveres M, Targa C. Lacunar infarcts in patients aged 85 years and older. Acta Neurol Scand. 2000 Jan;101(1):25-9.

13. Tejada J, Martinez V, Fernandez F, Hernandez L, Balboa O, Martinez L, et al. Lacunar infarcts. A comparative study of risk factors and carotid stenosis. Rev Clin Esp. 1995 Mar;195(3):141-6.

14. Hayreh SS, Servais GE, Virdi PS. Retinal arteriolar changes in malignant arterial hypertension. Ophthalmologica. 1989,198:178-96.

15. Hayreh SS, Servais GE, Virdi PS, Marcus ML, Rojas P, Woolson RF. Fundus lesions in malignant hypertension. III. Arterial blood pressure, biochemical, and fundus changes. Ophthalmology. 1986;93:45-59.

16. Walsh JB. Hypertensive retinopathy. Description, classification and prognosis. Ophthalmology. 1982;89:1127-31.

17. Klein R, Klein BE, Moss SE, Wang Q. Hypertension and retinopathy, arteriolar narrowing, and arteriovenous nicking in a population. Arch Ophthalmol. 1994;112:92-8.

18. Sheie HG. Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. Arch Ophthalmol. 1953;49:117-38.

19. Hayreh SS. Classification of hypertensive fundus changes and their order of appearance. Ophthalmologica. 1989;198:247-60.

20. Akman A, Kadaeifeilar S, Aydin P. Effect of hypertension of retinal reiwessdith arteric venus crossings. Eur J Oftalmolth. 1998 abr-jun 8(2):71-75.

21. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology. 1982;89:1132-45.

22. Akman A, Kadayifcilar S, Aydin P. Effects of hypertension on the retinal vein width at the retinal arterio-venous crossings. Eur J Ophthalmol. 1998 Apr-Jun;8(2):71-5.

23. Hajat C, Dundas R, Stewart JA, Lawrence E, Rudd AG, Howard R, et al. Cerebrovascular risk factors and stroke subtypes: differences between ethnic groups. Stroke. 2001 Jan;32(1):37-42.

24. Mule G, Nardi E, Andronico G, Cottone S, Raspanti F, Piazza G, et al. Relationships between 24 h blood pressure load, complications and and target organ damage in patients with mild-to-moderate essential hypertension and lacunar stroke. Blood Press Monit. 2001 Jun;6(3):115-23.

25. Yamamoto Y, Akiguchi I, Oiwa K, Hayashi M, Imai K. Twenty-four-hour blood pressure changes in the course of lacunar disease. Correlation with complication in long term. Cerebrovasc Dis. 2001;11(2):100-6.

26. Ruiz-Irastorza G, Khamashta MA. Related Articles, Links Stroke and antiphospholipid syndrome: the treatment debate. Rheumatology (Oxford). 2005 Aug;44(8):971-4.

27. Cook C, Stickley L, Ramey K, Knotts VJ. A variables associated with occupational and physical therapy stroke rehabilitation utilization and outcomes. J Allied Health. 2005 Spring;34(1):3-10.

28. Dobkin BH. Neurobiology of rehabilitation. Ann N Y Acad Sci. 2004 Dec;1038:148-70.

29. Jackson SP, Schoenwaelder SM, Goncalves I. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005 Apr;17:30-38.

30. Andersen G, Ostergaard L. [Thrombolytic therapy of acute ischemic apoplexy. Danish Society of Neurology] Ugeskr Laeger. 2005 Mar 21;167(12-13):1398.

31. Manno EM, Atkinson JL, Fulgham JR, Wijdicks EF. Emerging medical and surgical management strategies in the evaluation and treatment of intracerebral hemorrhage. Mayo Clin Proc. 2005 Mar;80(3):420-33.

32. Rakel. Guidelines for the management of intracerebral hemorrhage. 54 ed. Philadelphia: W.B. Saunders Co; 2002.

33. Davis SM, Kaye AH. Therapy for intracerebral hemorrhage. J Clin Neurosci. 2005 Apr;12(3):219-20.

34. Broderick JP. Advances in the treatment of hemorrhagic stroke: a possible new treatment. Cleve Clin J Med. 2005 Apr;72(4):341-4.

35. Ciappetta P, Paolini S. Intracerebral hematoma and aneurysms. J Neurosurg. 2005 Mar;102(3):582-3.

36. Antoniou D. Intracerebral hematoma and aneurysms. J Neurosurg. 2005 Mar;102(3):582.

37. Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24;352(8):777-85.

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How to Cite

1.
Treto Rosal J, Pérez López AH. Small vessel disease in the central nervous system. Acta Méd Centro [Internet]. 2007 May 1 [cited 2025 Jul. 6];1(1):82-9. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/326

Issue

Vol. 1 No. 1 (2007): May-August

Section

Review Articles

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