Pathologic examination of the liver in 200 deaths and severe with severe sepsis at high risk

Authors

  • Juan Miguel Rodríguez Rueda Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba
  • Teresita de Jesús Montero González Hospital Militar “Dr. Luis Díaz Soto”, Habana del Este, La Habana.
  • Ygnacio Paulino Ygualada Correa Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba
  • Ada Nersys Consuegra Carvajal Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Keywords:

liver, sepsis, mortality

Abstract

Introduction: Sepsis is a systemic response of host to infection that can lead to severe sepsis and septic shock. The liver is a target organ damage from sepsis.
Objective: To determine the histopathological characteristics of the liver in those who died with severe and severe sepsis at high risk and relate them to the location of the site of infection and the presence of icterus.
Methods: A retrospective, observational, descriptive study in 200 deaths from sepsis. Liver histological patterns were determined and related to the location of the site of infection and icterus and Chi square test was applied.
Results: Infiltration by mononuclear was observed in 79%, followed by 78.5% isolated necrosis, sinusoidal dilatation in 74% and 72.5% with hyperplasia of Kupffer cells. The icterus was associated with macrovesicular steatosis (p<0.01) and with migration of neutrophil to sinusoids (p<0.05) and abdominal sepsis with apoptosis of hepatocyte and with the microvesicular and macrovesicular steatosis.
Discussion: sepsis affects directly the structures and functions of the liver. Intra-abdominal sepsis was associated with apoptosis, while the icterus was associated with macrovesicular steatosis and with migration of neutrophil to sinusoids.

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Author Biographies

Juan Miguel Rodríguez Rueda, Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Medicina Interna. Especialista de II Grado en Medicina Intensiva y Emergencia. Máster en Urgencias Médicas. Profesor Auxiliar de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

Teresita de Jesús Montero González, Hospital Militar “Dr. Luis Díaz Soto”, Habana del Este, La Habana.

Especialista de II Grado en Anatomía Patológica. Doctora en Ciencias. Profesora Titular de la Universidad de Ciencias Médicas de La Habana.

Ygnacio Paulino Ygualada Correa, Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de II Grado en Anatomía Patológica, Doctor en Ciencias. Profesor Auxiliar de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

Ada Nersys Consuegra Carvajal, Hospital Militar Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Anestesiología y Reanimación. Máster en Urgencias Médicas. Profesora Asistente de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

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Published

2016-02-27

How to Cite

1.
Rodríguez Rueda JM, Montero González T de J, Ygualada Correa YP, Consuegra Carvajal AN. Pathologic examination of the liver in 200 deaths and severe with severe sepsis at high risk. Acta Méd Centro [Internet]. 2016 Feb. 27 [cited 2025 Jun. 28];10(1):9-16. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/329

Issue

Vol. 10 No. 1 (2016): January-March

Section

Original Articles

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