Liver damage, relationship to multiple damage of organs failure in 1143 died by sepsis

Authors

  • Juan Miguel Rodríguez Rueda Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba
  • Ygnacio Paulino Ygualada Correa Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba
  • Teresita de Jesús Montero González Hospital Militar “Dr. Luis Díaz Soto”, Habana del Este, La Habana, Cuba
  • Ada Nersys Consuegra Carvajal Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Keywords:

sepsis, multiple organ failure, liver failure

Abstract

Alterations in immune regulation in the liver and digestive tract predispose to multiple damage of organs and hinder its resolution. The clinical appearance of hepatic dysfunction may be delayed with respect to the beginning of sepsis, worsen the clinical course of the patient and promoting the emergence of multiple damage of organs. 1143 autopsies of deceased were analyzed with sepsis -the Automated System for Registration and Control of pathologically Anatomy was used- and it is emphasized in the histological diagnosis of the liver, in which the most obvious structural alterations were reactive hepatitis, hepatic steatosis and hepatic cholestasis, always related to sepsis. The relationship of these structural patterns of the liver of patients with severe sepsis and multiple damage of organs were checked. All who developed multiple damage of organs presented reactive hepatitis, 39.62% of patients with hepatic steatosis and 33.33% of patients with hepatic cholestasis developed multiple damage of organs.

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Author Biographies

Juan Miguel Rodríguez Rueda, Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Medicina Interna. Especialista de I y II Grado en Medicina Intensiva y Emergencia. Máster en Urgencias Médicas. Profesor Auxiliar de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

Ygnacio Paulino Ygualada Correa, Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Anatomía Patológica. Doctor en Ciencias. Profesor Auxiliar de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

Teresita de Jesús Montero González, Hospital Militar “Dr. Luis Díaz Soto”, Habana del Este, La Habana, Cuba

Especialista de I y II Grado en Anatomía Patológica. Doctora en Ciencias. Profesora Titular de la Universidad de Ciencias Médicas de la Habana.

Ada Nersys Consuegra Carvajal, Hospital Clínico Quirúrgico “Comandante Manuel Fajardo Rivero”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Anestesiología y Reanimación. Máster en Urgencias Médicas. Profesora Asistente de la Universidad de Ciencias Médicas “Dr. Serafín Ruiz de Zárate Ruiz” de Villa Clara.

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Published

2016-04-26

How to Cite

1.
Rodríguez Rueda JM, Ygualada Correa YP, Montero González T de J, Consuegra Carvajal AN. Liver damage, relationship to multiple damage of organs failure in 1143 died by sepsis. Acta Méd Centro [Internet]. 2016 Apr. 26 [cited 2025 Jul. 1];10(2):17-22. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/438

Issue

Vol. 10 No. 2 (2016): April-June

Section

Original Articles

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