Prognostic factors and survival in the evolution of lupus nephritis: a 17-year study

Authors

  • José Francisco Martínez Delgado Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba
  • Marta Pérez de Alejo Rodríguez Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba
  • Eddy Silverio Martínez Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Keywords:

lupus nephritis/therapy, prognosis, survivorship

Abstract

Renal and central nervous system manifestations give the systemic lupus erythematosus increased severity and define the prognosis. Renal involvement varies from latent or asymptomatic forms to rapidly progressive ones with renal failure and death. This work is aimed at describing the behavior of the evolution, prognosis and survival in a group of patients with lupus nephritis treated at the Arnaldo Milian Castro Provincial University Hospital in Villa Clara, during the period from February 1991 to April 2008. A longitudinal descriptive study was carried out with a sample of 58 patients suffering from the illness. These patients had clinical, laboratory and histological diagnoses of lupus nephritis. The WHO classification was used. Fifty three patients were female (91.37%) and 5 male (8.63%). Nine patients died (15.5%) and the survival (53.44%) is below 6 years of evolution. Grade III and IV nephritis represented 53.44% of all cases. The treatment options used included prednisone, imuran and cyclophosphamide, isolated or in combination. Renal involvement in this illness is an important prognostic factor for patients who suffer from it.

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Author Biographies

José Francisco Martínez Delgado, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Medicina Interna. Profesor Titular de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Marta Pérez de Alejo Rodríguez, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Especialista I y II Grado en Medicina Interna. Máster en Educación Médica Superior. Profesora Auxiliar de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Eddy Silverio Martínez, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Medicina Interna. Profesor Auxiliar de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

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How to Cite

1.
Martínez Delgado JF, Pérez de Alejo Rodríguez M, Silverio Martínez E. Prognostic factors and survival in the evolution of lupus nephritis: a 17-year study. Acta Méd Centro [Internet]. 2010 Oct. 11 [cited 2025 Jul. 2];4(4):21-7. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/531

Issue

Vol. 4 No. 4 (2010): October-December. Special Issue of Internal Medicine

Section

Original Articles

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