Characterization of neoplastic diseases in patients with functional renal transplantation
Keywords:
neoplasms, kidney transplantationAbstract
Introduction: renal transplantation is the therapy of choice for the majority of patients with chronic renal failure. Immunosuppressive treatment shows associations with neoplastic diseases. Objective: to characterize neoplastic diseases in patients with functional renal transplantation. Method: an observational, descriptive, transverse study was carried out at "Arnaldo Milián Castro" Hospital. An intentional sample of 16 patients with neoplastic diseases was selected. Information was obtained from the renal transplant Consultation, from the clinical file and database of the Department of Pathological Anatomy. Results: male sex predominated (81%), mean age higher than female sex, and white skin color (93.7%). The most commonly used renal replacement therapy was hemodialysis (nine, 56%). Squamous cell carcinoma (six) and basal cell (three) prevailed. The frequency of viral diseases such as hepatitis C and cytomegalovirus was evidenced. Immunosuppressive treatment with prednisone, immuran, and cyclosporin was more than half of the patients (62%), and seven died after three years of neoplastic disease treatment for each patient. Conclusions: squamous cell carcinoma and basal cellular carcinoma were the most prevalent neoplastic diseases and after the treatment received, the survival was the expected.Downloads
References
1. García-García G, Harden P, Chapman J. El papel global del trasplante renal. Nefrología (Madr) [Internet]. 2012 [citado 15 May 2015];32(1):[aprox. 8 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952012000100001
2. Rivas R, Martínez Torres A, Mármol A, Vilá MP. Influencia del modelo español en la organización del Programa Cubano de Trasplante Renal. Nefrologia (Madr) [Internet]. 2001[citado 15 May 2015];21 Supl 4:148-50. Disponible en: http://www.revistanefrologia.com/es-publicacion-nefrologia-articulo-influencia-del-modelo-espanol-organizacion-del-programa-cubano-trasplante-renal-X0211699501027002
3. Pascual J, Cruzado JM, Alonso Á, Diekman F, Gallego RJ, Gutiérrez-Dalmau Á, et al. El Grupo de Trasplante Renal de la Sociedad Española de Nefrología. Nefrología (Madr.) [Internet]. 2013 [citado 4 Mar 2015];33(2):[aprox. 6 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952013000200002&lng=es
4. Zwald FO, Brown M. Skin cancer in solid organ transplant recipients: advances in therapy and management: part I. Epidemiology of skin cancer in solid organ transplant recipients. J Am Acad Dermatol [Internet]. 2011 [citado 15 Nov 2015];65(2):253-61. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/21763561
5. Rodríguez-Acosta ED, Calva-Mercado JJ, Alberú Gómez J, Vilatobá Chapa M, Domínguez Cherit J. Pacientes con trasplante de órgano sólido y cáncer de piel: determinación de factores de riesgo con énfasis en la fotoexposición y el esquema inmunosupresor. Experiencia de un hospital de tercer nivel. Gac Méd Méx [Internet]. 2015 [citado 20 May 2015];151(1):20-6. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=5090343
6. Moreso F, Hernández D. ¿Ha mejorado la supervivencia del injerto tras el trasplante renal en la era de la moderna inmunosupresión? Nefrología (Madr.) [Internet]. 2013 [citado 4 Mar 2015];33(1):14-26. Disponible en: http://www.revistanefrologia.com/es-publicacion-nefrologia-articulo-ha-mejorado-supervivencia-del-injerto-tras-el-trasplante-renal-era-X0211699513002692
7. Hardinger K, Brennan DC, Klein CL. Selection of induction therapy in kidney transplantation. Transpl Int [Internet]. 2013 [citado 15 May 2015];26(7):662–672. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/23279211
8. Ruiz Díaz MJ, Fernández Castillo Rl, Esteban RJ, Fernández Gallegos R, Esteban MA, Bravo Soto J. Epidemiología de la patología tumoral en el trasplante renal. Rev Nefrol Diálisis Transpl [Internet]. 2012 [citado 15 May 2015];32(4):214-212. Disponible en: https://www.researchgate.net/publication/289529942_Epidemiologia_de_la_patologia_tumoral_en_el_trasplante_renal
9. Otley CC, Berg D, Ulrich C, Stasco T, Murphy GM, Salasche SJ, et al. Reduction of inmunosuppression for transplant-associated skin cancer: expert consensus survey. Br J Dermatol [Internet]. 2006 [citado 15 May 2015];154(3):395-400. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/16445766
10. Hosseini-Moghaddam SM, Soleimanirahbar A, Mazzulli T, Rotstein C, Husain S. Post renal transplantation Kaposi's sarcoma: a review of its epidemiology, pathogenesis, díagnosis, clinical aspects, and therapy. Transpl Infect Dis [Internet]. 2012 [citado 15 May 2015];32(1):14(4):338-45. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/22316356
11. Berg D, Otley CC. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol [Internet]. 2002 [citado 15 May 2015];47(1):1-17. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/12077575
12. Bernat-García J, Morales Suárez-Varela M, Vilata-Corell JJ, Marquina-Vila A, Pallardo L, Crespo J. Papel de los nuevos agentes inmunosupresores en el cáncer cutáneo no melanoma en pacientes trasplantados renales. Actas Dermo-Sifiliográficas [Internet]. 2014 [citado 20 May 2015];105(10):940-946. Disponible en: http://www.sciencedirect.com/science/article/pii/S0001731014003147
13. Hernández D, Martínez D, Gutiérrez E, López V, Gutiérrez C, García P. et al. Evidencias clínicas sobre el uso de los fármacos anti-mTOR en el trasplante renal. Nefrología (Madr.) [Internet]. 2011 [citado 20 May 2015];31(1):[aprox. 12 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952011000100005
14. Araki K, Turner AP, Oliva Shaffer V, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature [Internet]. 2009 [citado 15 May 2015];460:108-112. Disponible en: http://www.nature.com/nature/journal/v460/n7251/full/nature08155.html
15. Bansal SB, Saxena V, Pokhariyal S, Gupta P, Kher V, Ahlawat R, et al. Comparison of azathioprine with mycophenolate mofetil in a living donor kidney transplant programme. Indian J Nephrol [Internet]. 2011 [citado 15 Abr 2016];32(1):21(4):258-263. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193669/
16. Ojo AO, Morales JM, González-Molina M, Steffick DE, Luan FL, Merion RM, et al. Comparison of the long-term outcomes of kidney transplantation: USA versus Spain. Nephrol Dial Transplant [Internet]. 2013 [citado 15 May 2016];28(1):213-20. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/22759384
How to Cite
Issue
Section
License
Authors who have publications with this journal agree to the following terms:
- Authors will retain their copyright and assign to the journal the right of first publication of their work, which will simultaneously be subject to a Creative Commons License / Attribution-Noncommercial 4.0 International (CC BY-NC 4.0) that allows third parties to share the work as long as its author and first publication in this journal are indicated.
- Authors may adopt other non-exclusive license agreements for distribution of the published version of the work (e.g., depositing it in an institutional repository or publishing it in a monographic volume) as long as the initial publication in this journal is indicated.
- Authors are allowed and encouraged to disseminate their work through the Internet (e.g., in institutional telematic archives or on their web page) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).