Genome-environment Interaction in type 2 Diabetes Mellitus
Keywords:
diabetes mellitus, type 2, gen-environment interaction, epidemiologyAbstract
Introduction: type 2 diabetes mellitus is the predominant form of diabetes worldwide. It is a heterogeneous syndrome of multifactorial etiology that combines genetic and environmental factors and it is increasingly important due to its morbidity, mortality and disabling effects, which affect the quality of life of those who suffer from it and of their relatives, and due to the use of medical services. Objective: to identify the contribution of the genome-environment interaction in the genesis of type 2 diabetes mellitus in patients of the Puentes Grandes Polyclinic. Methods: an analytical study of population-based case-control was conducted from February 2015 to March 2016 at the Puentes Grandes Polyclinic. Information was obtained from a written questionnaire and the review of individual medical records. We conducted a study that included 60 cases and 120 controls. Results: the existence of familial aggregation in type 2 diabetes mellitus was confirmed, the risk of suffering the disease was 3.6 times higher when a first degree relative was affected and 3.02 times higher when the risk factor of obesity was present and the risk of becoming ill was 14.12 times higher when genetic and environmental factors were overlapped. Conclusions: Type 2 diabetes mellitus is more likely to appear when genetic and environmental factors coincide because it is a multifactorial disease in which the presence of genetic factors is not enough, but the action of a predisposing environment is required to appear.Downloads
References
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