Nutrigenomics and nutrigenetics: the path to personalized nutrition

Authors

Keywords:

nutrigenomics, nutrigenetics, personalized nutrition

Abstract

Introduction: The application of molecular biology techniques and the success of the Human Genome Project have opened a new era in both medicine and nutrition. Progress in nutrigenomics and nutrigenetics will be linked to the use of personalized diets to delay the onset of disease and optimize the maintenance of human health.
Objectives: To address the development of the Omic Sciences and explain the differences between the concepts of nutrigenomics and nutrigenetics and their relationship to the concept of personalized nutrition.
Method: A bibliographic review of texts compiled in the Medline, Lilacs, and Cochrane databases was conducted.
Development: Nutritional sciences have highlighted the relationship between diet, nutrition, and health. When reviewing the scientific literature that covers the interactions between genes and nutrients and between diet, its components, and the genome, it is striking that the terms that appear in many publications and their definitions sometimes lead to a certain degree of confusion.
Conclusions: After reviewing current knowledge of nutritional genomics, we see that the first steps have been taken in this new, exciting, and promising field of personalized nutrition. In any case, and not in the near future, the integration of genomics into nutritional sciences will increase the effectiveness of nutritional interventions, both at the clinical and population levels.

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Author Biography

Noel Taboada Lugo, Provincial Center for Medical Genetics of Villa Clara, Cuba.

Specialist in Comprehensive General Medicine, Degree I and II. Specialist in Clinical Genetics, Degree I and II. Doctor of Medical Sciences. Master's Degree in Comprehensive Child Care. Professor of Medical Genetics at the University of Medical Sciences of Villa Clara. Provincial Center for Medical Genetics of Villa Clara, Cuba.

References

1- Martí A, Moreno-Aliaga J, Zulet MA, Martínez JA. Avances en nutrición molecular: nutrigenómica y/o nutrigenética. Nutr Hosp [Internet]. 2005 [citado 29/06/2024]; 20(3): [aprox. 3p.]. Disponible en: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112005000400001

2- Sánchez ZE. Epigenética: conectando nutrición con programación fetal [Tesis]. Valladolid: Universidad de Valladolid; 2023 Disponible en: https://uvadoc.uva.es/bitstream/handle/10324/61306/TFG-M-N3097.pdf?sequence=1&isAllowed=y

3- Castillo C. Interacciones entre los principales polimorfismos asociados con la obesidad y la dieta: una revisión sistemática [Tesis]. Buenos Aires: Universidad Nacional de La Plata; 2024 Disponible en: https://sedici.unlp.edu.ar/bitstream/handle/10915/161942/Documento_completo.pdf-PDFA.pdf?sequence=1&isAllowed=y

4- Marcum JA. Nutrigenetics/Nutrigenomics, personalized nutrition, and precision healthcare. Curr Nutr Rep [Internet]. 2020 [citado 29/06/2024]; 9:[aprox.3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32578026/

https://doi.org/10.1007/s13668-020-00327-z

5- Chaudhary S, Chaudhary P, Patel S. Genomics, transcriptomics, proteomics and metabolomics approaches. In: Naeem M, Aftab T, Khan MMA. Fenugreek. Biology and applications [Internet]. Singapore: Springer. Disponible en: https://link.springer.com/book/10.1007/978-981-16-1197-1

https://doi.org/10.1007/978-981-16-1197-1_16

6- Meiliana A, Wijaya A. Nutrigenetics, nutrigenomics and precision nutrition. Indones Biomed J [Internet]. 2020 [citado 29/06/2024]; 12(3): [aprox. 3p.]. Disponible en: https://inabj.org/index.php/ibj/article/view/1158

7- Lagoumintzis G, Patrinos GP. Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living. Hum Genomics [Internet]. 2023 [citado 29/06/2024]; 17(1): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/38062537/

https://doi.org/10.1186/s40246-023-00561-w

8- Mehta NH, Huey SL, Kuriyan R, Peña-Rosas JP, Finkelstein JL, Kashyap S, et al. Potential mechanisms of precision nutrition-based interventions for managing obesity. Adv Nutr [Internet]. 2024 [citado 29/06/2024]; 15(3): [aprox. 2p.] Disponible en: https://doi.org/10.1016/j.advnut.2024.100186

9- Dhanapal AT, Wuni R, Ventura EF, Chiet TK, Cheah ESG, Loganathan A, et al. Implementation of nutrigenetics and nutrigenomics research and training activities for developing precision nutrition strategies in Malaysia. Nutrients [Internet]. 2022 [citado 29/06/2024]; 14(23):[aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36501140/

https://doi.org/10.3390/nu14235108

10- Ferguson L, Barnett M. Nutrigenomics and nutrigenetics research in New Zealand, and its relevance and application to gastrointestinal health. Nutrients [Internet]. 2022 [citado 29/06/2024]; 14(9): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35565709/

https://doi.org/10.3390/nu14091743

11- Aldaya MM, Beriain MJ. Hacia una alimentación sana y sostenible. Rev Esp Nutr Hum Diet [Internet]. .2021 [citado 29/06/2024]; 25(Supl. 3): [aprox. 2p.]. Disponible en: https://renhyd.org/renhyd/article/view/1595

12- Mullins VA, Bresette W, Johnstone L, Hallmark B, Chilton FH. Genomics in personalized nutrition: can you "eat for your genes"? Nutrients [Internet]. 2020 [citado 29/06/2024]; 12(10): [aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33065985/

https://doi.org/10.3390/nu12103118

13- McGuire AL, Gabriel S, Tishkoff SA, Wonkam A, Chakravarti A, Furlong EEM, et al. The road ahead in genetics and genomics. Nat Rev Genet [Internet]. 2020 [citado 29/06/2024]; 21(10): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32839576/

https://doi.org/10.1038/s41576-020-0272-6

14- Habib N, Idrissi Azami A, Aberkani K, Motaib I, Bakkali F, Ghazal H. Nutrigenomics and transcriptomics for a personalized nutrition. In: Chatoui H, Merzouki M, Moummou H, Tilaoui M, Saadaoui N, Brhich A. Nutrition and Human Health [Internet]. Berlín: Springer International Publishing; 2022. Disponible en: https://www.springerprofessional.de/correction-to-nutrigenomics-and-transcriptomics-for-a-personaliz/23436476

https://doi.org/10.1007/978-3-030-93971-7_24

15- Gürsoy G, Li T, Liu S, Ni E, Brannon CM, Gerstein MB.Functional genomics data: privacy risk assessment and technological mitigation. Nat Rev Genet [Internet]. 2022 [citado 29/06/2024]; 23(4): [aprox. 2p.] Disponible en: https://pubmed.ncbi.nlm.nih.gov/34759381/

https://doi.org/10.1038/s41576-021-00428-7

16- Pazmiño JD. Perspectivas dietéticas de la alimentación materna prenatal en el desarrollo del ámbito autista [Tesis]. Ecuador: Universidad Técnica de Ambato; 2023. Disponible en: https://repositorio.uta.edu.ec/bitstream/123456789/38867/1/Pazmi%c3%b1o%20Pe%c3%b1a%20Joel%20David.pdf

17- Jiang J, Chen B, Tang B, Wei Q. Selenium in prostate cancer: prevention, progression, and treatment. Pharmaceuticals (Basel) [Internet]. 2023 [citado 29/06/2024]; 16(9):[aprox. 2p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37765058/

https://doi.org/10.3390/ph16091250

18- Kiani AK, Bonetti G, Donato K, Kaftalli J, Herbst KL, Stuppia L, et al. Polymorphisms, diet and nutrigenomics. J Prev Med Hyg [Internet]. 2022 [citado 29/06/2024]; 63(2 Suppl 3): E125-E141. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC9710387/

https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2754

19- Rahawi S, Naik H, Blake KV, Owusu Obeng A, Wasserman RM, Seki Y, et al. Knowledge and attitudes on pharmacogenetics among pediatricians. J Hum Genet [Internet]. 2020 [citado 29/06/2024]; 65(5): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31983733/

https://doi.org/10.1038/s10038-020-0723-0

20- Gabbianelli R, Bordoni L, Morano S, Calleja-Agius J, Lalor JG. Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced? Int J Mol Sci [Internet]. 2020 [citado 29/06/2024]; 21(14): [aprox. 3p.]. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7404045/

https://doi.org/10.3390/ijms21145032

21- Taboada Lugo N. Factores epigenéticos involucrados en el origen de defectos congénitos relacionados con la deficiencia materna de ácido fólico y otros micronutrientes. Acta Med Centro [Internet]. 2019 [citado 29 /06/2024]; 13(3): [aprox. 2p.] Disponible en: https://scielo.sld.cu/pdf/amdc/v13n3/2709-7927-amdc-13-03-439.pdf

22- Divella R, Danielle A, Savino E, Paradiso A. Anticancer effects of nutraceuticals in the Mediterranean diet: An epigenetic diet model. Cancer Genomics Proteomics [Internet]. 2020 [citado 29/06/2024]; 17(4): [aprox. 3p.]. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7367609/

https://doi.org/10.21873/cgp.20193

23- Taboada Lugo N. Factores genéticos y ambientales en madres con descendencia afectada por defectos congénitos folato-sensibles en Villa Clara [Tesis]. Santa Clara: Universidad de Ciencias Médicas de Villa Clara; 2022 Disponible en: https://tesis.sld.cu/index.php/index.php?P=FullRecord&ID=2076

24- Taboada Lugo N, Herrera MM, Ferreira CRP, Almaguer MLE, Collazo MT, Gómez MM. Association between maternal C677T (rs1801133) polymorphism and neural tube defects in Villa Clara, Cuba: A population-based study. EC Gynaecol [Internet]. 2023 [citado 29/06/2024]; 12(2): [aprox. 2p.] Disponible en: https://ecronicon.net/ecgy/assocation-between-maternal-c677t-rs180133-polymorphism-and-neural-tube-defects-in-villa-clara-cuba-a-population-based-study

25- Ghorbani M, Azghandi M, Khayami R, Baharara J, Kerachian MA. Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps. BMC Medical Genomics [Internet]. 2021 [citado 29/06/2024]; 14(1): [aprox. 3p.]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34645434/

https://doi.org/10.1186/s12920-021-01097-5

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Published

2025-06-01

How to Cite

1.
Taboada Lugo N. Nutrigenomics and nutrigenetics: the path to personalized nutrition. Acta Méd Centro [Internet]. 2025 Jun. 1 [cited 2025 Jul. 1];19(1):r2064. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/e2064

Issue

Vol. 19 (2025): PUBLICACIÓN CONTINUA

Section

Review Articles

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