Value of lyophilized morphine in myocardial revascularization

Authors

  • Rudy Hernández Ortega Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba
  • Osvaldo González Alfonso Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba
  • Pedro A. Hidalgo Menéndez Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba
  • Ilida M. Marrero Font Clínica Estomatológica “Celia Sánchez Manduley”, Santa Clara, Villa Clara, Cuba
  • Elvis González Pérez Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba
  • Juan Manuel Rodríguez Álvarez Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba

Keywords:

myocardial revascularization, morphine/administration & dosage, evaluation of the efficacy-effectiveness of interventions

Abstract

Introduction: epidural analgesia is a mainstay in cardiac surgery. Objectives: The aim of this study was to compare the use of lyophilized morphine and epidural bupivacaine in postoperative analgesia of myocardial revascularization. Method: A comparative and prospective study was conducted in 160 patients. They were divided into two groups: group M received epidural analgesia with morphine (2 mg) associated with 100 mg of bupivacaine, and group B bupivacaine only. Results: there was a prevalence of males. The ages and the average weights of both groups were similar (p>0.05). In group M, 90% of patients had excellent analgesia eight hours after the intervention, and it was good to excellent after 12 and 24 hours. On the other hand, 50% of patients in group B talked of an average analgesia eight hours after the operation –which extended to 80% of patients after 12 hours– and, after 24 hours, all the patients in group B complained of an inadequate or poor analgesia (p<0.05). The average postoperative analgesia obtained in group M was 29.41 hours, and 9.76 hours in group B (p<0.01). The main adverse events were hypotension and bradycardia. Conclusions: Morphine showed its usefulness as an analgesic agent in the surgical operation of the coronary arteries. Patients with epidural bupivacaine and morphine had a better analgesia with longer duration than those treated with bupivacaine only.

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Author Biographies

Rudy Hernández Ortega, Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Anestesiología y Reanimación. Máster en Urgencias Médicas. Profesor Asistente de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Osvaldo González Alfonso, Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Anestesiología y Reanimación. Máster en Urgencias Médicas. Profesor Auxiliar de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Pedro A. Hidalgo Menéndez, Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Anestesiología y Reanimación. Máster en Terapia Intensiva. Profesor Instructor de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Ilida M. Marrero Font, Clínica Estomatológica “Celia Sánchez Manduley”, Santa Clara, Villa Clara, Cuba

Especialista en Estomatología General Integral. Máster en Salud Bucal Comunitaria. Profesora Instructora de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Elvis González Pérez, Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa Clara, Cuba

Especialista de I y II Grado en Anestesiología y Reanimación. Máster en Urgencias Médicas. Profesor Auxiliar de la Universidad de Ciencias Médicas de Villa Clara “Dr. Serafín Ruiz de Zárate Ruiz”.

Juan Manuel Rodríguez Álvarez, Cardiocentro “Ernesto Che Guevara”, Santa Clara, Villa Clara, Cuba

Especialista de I Grado en Medicina General Integral. Especialista de I Grado en Anestesiología y Reanimación.

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How to Cite

1.
Hernández Ortega R, González Alfonso O, Hidalgo Menéndez PA, Marrero Font IM, González Pérez E, Rodríguez Álvarez JM. Value of lyophilized morphine in myocardial revascularization. Acta Méd Centro [Internet]. 2012 Jan. 5 [cited 2025 Jul. 1];6(1):55-64. Available from: https://revactamedicacentro.sld.cu/index.php/amc/article/view/671

Issue

Vol. 6 No. 1 (2012): January-March. Special Issue on Surgery

Section

Original Articles

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